Norethindrone 炔诺酮
CAS 68-22-4 MFCD00067596
化学结构图
SMILES: C[C@@]12CC[C@H]3[C@@H]4CCC(=O)C=C4CC[C@@H]3[C@H]1CC[C@]2(O)C#C |&1:1,4,5,14,15,18|
化学属性
| Mol. Formula | C20H26O2 |
|---|---|
| Mol. Weight | 298 |
| Melting Point | 205-206 |
| Solubility | DMSO 60 mg/mL Water <1 mg/mL Ethanol 5 mg/mL |
| Appearance | powder |
别名和识别编码
| Chemical Name | Norethindrone |
|---|---|
| CAS Number | 68-22-4 |
| Synonym | (17?)-17-Hydroxy-19-norpregn-4-en-20-yn-3-one (8R,9S,10R,13S, 17-Ethynyl-19-nortestosterone, 17-Hydroxy-19-nor-17-4-pregnen-20-yn-3-one, 17-Ethynyl-17-hydroxy-19-nor-4-androsten-3-one, 19-Nor-17-ethynyl-4-androsten-17-ol-3-one, 19-Norethisterone 17-HYDROXY-19-NOR-17ALPHA-4-PREGNEN-20-YN-3-ONE 17-Hydroxy-19-nor-17α-p 17-alpha-Ethinylestra-4-en-17-beta-ol-3-one 17-alpha-Ethynyl-17-beta-hydroxyestr-4-en-3-one 17-alpha-Ethynyl-4-estren-17-ol-3-one 17-hydroxy-19-nor-17a-pregn-4-en-20-yn-3-one 17ALPHA-ETHYNYL-19-NORTESTOSTERONE 17α-Eth 17α-Ethinyl-17β-hydroxy-Δ4-estren-3-one 17α-Ethinyl-19-nortestosterone 17α-Ethynyl-17-hydroxy-4-estrene-3-one 17α-Ethynyl-17-hydroxyest-4-en-3-one 17α-Ethynyl-17-hydroxyestr-4-en-3-one 17α-Ethynyl-17β-hydroxy-19-norandrost-4-en-3-one |
| MDL Number | MFCD00067596 |
| PubChem Substance ID | 24897669 |
| Beilstein Registry Number | 1915671 |
| EC Number | 200-681-6 |
| Chemical Name Translation | 炔诺酮 |
| Merck Number | 6697 |
| Wiswesser Line Notation | L E5 B666 OV MUTJ E FQ F1UU1 -A&F |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Analytical Standards,
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards N - O, Pharmaceutical Standards, Pharmacopeia Standards
- {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, N, Other Steroid Products, Steroid Hormones, 细胞生物学
- {SA} Alphabetic, Analytical Standards, Analytical/
- {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards N - O, 分析/色谱
- {SNA} Analytical Standards, Pha
产品应用
- Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen.
相关文献及参考
- Schroff, A. P., et al.: Anal. Profiles Drug Subs., 4, 268 (1975),
- Singh, H., et al.: Am. J. Obstet. Gynecol., 135, 409 (1979),
- Toews, M., et al.: Curr. Ther. Res, 41, 509 (1987),
- Merck 14 ,6697
- Beil. 8 ,IV,1221
- Corp MSDS 1 (2), 2625:C / FT-IR 2 (3), 4238:C / FT-NMR 1 (3), 591:B / RegBook 1 (2), 2867:D / Sax 6 , 1587 / Sigma FT-IR 1 (1), 1288:B / Structure Index 1 , 459:D:3
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H351 Suspected of causing cancer 怀疑致癌
- S22 Do not breathe dust 不要吸入粉尘；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Implant SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 166 mg/kg/77W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - increased incidence of tumors in susceptible strains REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 212,686,1966
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 163 mg/kg/78W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 21,153,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 168 mg/kg/78W-C TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - ovarian tumors REFERENCE : PMDFA9 Pakistan Medical Forum. (Karachi, Pakistan) V.1-8, 1966-73(?) Disc ontinued. Volume(issue)/page/year: 7,21,1972
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 42 mg/kg TOXIC EFFECTS : Endocrine - androgenic Skin and Appendages - dermatitis, other (after systemic exposure) REFERENCE : AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 84,962,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,809,1990
TYPE OF TEST : DNA inhibition TEST SYSTEM : Human Lymphocyte DOSE/DURATION : 50 umol/L REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 146,401,1974
其他信息
- 下游产品:
- MOL 文件:68-22-4.mol
- 上游原料:四氢呋喃
- 用途一:孕激素类药，用于月经不调、子宫功能性出血、子宫内膜异位症等
- color:white to off-white
- Sigma Aldrich:68-22-4(sigmaaldrich)
- 炔诺酮
