Vitamin B12 维生素B12
CAS 68-19-9 MFCD00151092
化学结构图
SMILES:
化学属性
| Mol. Formula | C63H88CoN14O14P |
|---|---|
| Mol. Weight | 1355.37 |
| Density | 0.945 |
| TSCA | Yes |
| Stability | 对热、湿度敏感 |
| Melting Point | >300°C |
| Solubility | Soluble in water (50 mg/ml), DMSO (75 mg/ml at 25 °C), and ethanol (10 mg/ml at 25 °C). Insoluble in chloroform, and acetone. |
别名和识别编码
| Chemical Name | Vitamin B12 |
|---|---|
| Synonym | Anacobin Berubigen Betalin 12 crystalline Betaline-12 Cotel Crystamin Cyanocobalamin, α-(5,6-Dimethylbenzimidazolyl)cyanocobamide Dimethy Dodecabee Duodecibin Embiol Erycytol Factor II Factor II (vitamin) Normocytin Sytobex Vibalt Vitamin B12 Vitamin B12 (Impurity) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {ALD} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {hazard_co α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cb α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cbl α-(5,6-Dimethylbenzimidazolyl)cyanocobamide CN-Cbl Cyanocob(III)alami |
| MDL Number | MFCD00151092 |
| CAS Number | 68-19-9 |
| EC Number | 200-680-0 |
| Beilstein Registry Number | 4122889 |
| PubChem Substance ID | 87565570 |
| Merck Number | 10014 |
| Chemical Name Translation | 维生素B12 |
| Reaxys-RN | 4122889 |
| InChIKey | GOXVFFNWRIUNJM-UHFFFAOYSA-L |
| Wiswesser Line Notation | D C5656 B-5 B6 B5 S5 J&5 B-19- Q&6 N&5/B-N/DU/J&-M&J&- O& 9ABBBBCSTT V& AN-CO-&& B-N CN TN C |
| LabNetwork Molecule ID | LN01740971 |
| Canonical SMILES | N#[C-][Co+3]123([N]4=CN(C(OC(CO)C5OP6([O-])=O)C5O)C7=C4C=C(C)C(C)=C7)[N]8=C9C(CCC(N)=O)C(CC(N)=O)(C)C8(C)C(C(CC(N)=O)C%10(CCC(NCC(C)O6)=O)C)[N-]1C%10=C(C)C(C(CCC(N)=O)C%11(C)C)=[N]2C%11=CC%12=[N]3C(C(CC(N)=O)(C)C%12CCC(N)=O)=C9C |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Food & Beverage Standards, Nutraceuticals, Pharmaceutical Secondary Standards, Pharmaceutical Standards, Vitamin B, Vitamins, Water-Soluble Vitamins
- {SNA} Nutrition Research, Vitamin B, Vitamin B12,
产品应用
- A coenzyme for synthesis of nucleic acids and metabolism carbohydrates.
相关文献及参考
- [2]. Banerjee, R. and S.W. Ragsdale, The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.
- For a review, see: Vitamins, W. Friedrich, Ed., de Gruyter, Berlin (1988), pp 837-928.
- For monographs, see: B 12 (2 vols), D. Dolphon, Ed., Wiley-Interscience, N.Y. (1982); B 12 and B 12 -Proteins, B. Kraeutler, T Golding, Eds., Wiley-VCH, Weinheim (1998).
- For review of biosynthesis, see: Angew. Chem. Int. Ed., 32, 1223 (1993).
- Merck: 14,10014
- Merck: 14,10014 Beilstein: 26,IV,3117
- [1]. http://en.wikipedia.org/wiki/Vitamin_B12
- [1]. http://en.wikipedia.org/wiki/Vitamin_B12
- [2]. Banerjee, R. and S.W. Ragsdale, The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annu Rev Biochem, 2003. 72: p. 209-47.
安全信息
GHS Symbol
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1364 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - excitement REFERENCE : ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2727 ug/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - chronic pulmonary edema Blood - other changes REFERENCE : ARPAAQ Archives of Pathology. (Chicago, IL) V.5(3)-50(3), 1928-50; V.70-99, 1960-75. For publisher information, see APLMAS. Volume(issue)/page/year: 49,278,1950
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >5 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,114,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE : 84 mg/kg SEX/DURATION : female 11 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE : 168 mg/kg SEX/DURATION : female 10 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,377,1978
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 115 mg/kg SEX/DURATION : female 1-22 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) Reproductive - Effects on Newborn - biochemical and metabolic REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 242,263,1973
其他信息
- 300℃不溶化。有吸湿性，在空气中能吸收12%水分，其含水结晶在空气中稳定。在210-220℃时颜色变深。能溶于水和醇，不溶于丙酮、氯仿和醚。其溶液呈中性，在pH4.5-5时最稳定。在碱性或强酸性溶液中可缓缓水解。无臭，无味。
- Vitamin B12 (Cyanocobalamin) is part of a coenzyme needed for the synthesis of proteins and nucleic acids, and for the metabolism of carbohydrates. Vitamin B12 plays a role in the synthesis of myelin. The compound is also used as an antipernicious anemia factor.
