(±)-Norverapamil hydrochloride
CAS 67812-42-4 MFCD00078605
化学结构图
SMILES: [2H]C(C(CCCNCCC1C=CC(OC)=C(C=1)OC)(C#N)C1C=C(OC)C(=CC=1)OC)(C([2H])([2H])[2H])C([2H])([2H])[2H]
化学属性
| Mol. Formula | C26H36N2O4· HCl |
|---|---|
| Mol. Weight | 477.04 |
别名和识别编码
| Chemical Name | (±)-Norverapamil hydrochloride |
|---|---|
| Synonym | (±)-Norverapamil hydrochloride N-Nor-(±)-verapamil hydrochloride |
| MDL Number | MFCD00078605 |
| PubChem Substance ID | 24900707 |
| Chemical Name Translation | |
| CAS Number | 67812-42-4 |
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分类
- {SNA} Bioactive Small Molecules, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Ion Channels, N, Verapamil, Voltage-gated Ion Channels
- {SNA} Bioactive Small Molecule Alphabetical Index, Calcium Channel Modulators, Ion Channels, N, Verapamil,
相关文献及参考
- [2]. Pauli-Magnus C, et al. Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein. J Pharmacol Exp Ther. 2000 May;293(2):376-82.
- [3]. Wang J et al. A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human. Eur J Pharm Sci. 2013 Nov 20;50(3-4):290-302.
- [4]. Choi DH, et al. Effects of simvastatin on the pharmacokinetics of verapamil and its main metabolite, norverapamil, in rats. Eur J Drug Metab Pharmacokinet. 2009 Jul-Sep;34(3-4):163-8.
- [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-me
- [1]. Adams KN, et al. Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs. J Infect Dis. 2014 Aug 1;210(3):456-66.
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
GHS Symbol
- P301+P312+P330
- P305+P351+P338
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
