CAS 66085-59-4 MFCD00153848-Nimodipine 尼莫地平 TAO{mole}

Nimodipine 尼莫地平

CAS 66085-59-4 MFCD00153848

化学结构图

SMILES: CC(C)OC(=O)C1C(C(C(=O)OCCOC)=C(C)NC=1C)C1=CC(=CC=C1)[N+]([O-])=O

化学属性

Mol. Formula	C21H26N2O7
Mol. Weight	418
TSCA	No
Melting Point	124-128

别名和识别编码

Chemical Name	Nimodipine
CAS Number	66085-59-4
Alfabeta Name	ISOPROPYLMETHOXYETHYLDIMETHYLNITROPHENYLDIHYDROPYRIDINEDICARBOXYLATE 226431435()---------,,,
MDL Number	MFCD00153848
Synonym	Isopropyl 2-Methoxyethyl 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl 1-methylethyl ester
PubChem Substance ID	135727105
EC Number	266-127-0
Merck Number	6551
Reaxys-RN	459792
Chemical Name Translation	尼莫地平
Beilstein Registry Number	459792

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产品应用

A dihydropyridine calcium channel blocker. It is used as a vasodilator (cerebral).

安全信息

Warnings IRRITANT

RTECSUS7975500

GHS Symbol

Hazard statements

H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
H303 May be harmfully swallowed 吞食可能有害

WGK Germany1

Signal word

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Risk Statements

Safety Statements

S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Storage condition Light Sensitive

Precautionary statements

P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 26200 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 19,6899,1985

TYPE OF TES

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 9500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 19,6899,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   54,275,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 4 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 36,1733,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUT

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 528 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 22 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   9,39,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 132 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 22 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis.  (Alan R. Liss, Inc.,
   41 E. 11th St., New York, NY 10003)  V.1-    1980- Volume(issue)/page/year:
   9,39,1989