MEOSUC-ALA-ALA-PRO-VAL-CHLOROMETHYLKETONE

CAS 65144-34-5 MFCD00077136

化学结构图

65144-34-5
SMILES: CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)OC)C(=O)CCl

化学属性

Mol. FormulaC22H35ClN4O7
Mol. Weight502.99
Melting Point159-161 °C

别名和识别编码

Chemical NameN-(Methoxysuccinyl)-Ala-Ala-Pro-Val-chloromethyl ketone
Synonym N-(Methoxysuccinyl)-L-alanyl-L-alanyl-L-prolyl-L-valine chloromethylketone
MDL NumberMFCD00077136
PubChem Substance ID24896552
Beilstein Registry Number6167019
CAS Number65144-34-5
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分类

  • {SNA} Cytoskeleton and Extracellular Matrix, D to K, Elastase, granulocyte, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Extracellular Matrix, Metalloproteinase Inhibitors, Protease Inhibitor Specificity Index, Protease Inhibitors, 生化试剂, 细胞信号转导和神经科学, 细胞生物学, 酶、抑制剂和底物
  • Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, D to K, Elastase, granulocyte, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, Extracellular Matrix,

相关文献及参考

  • 1. Stein, R.L., and Trainor, D.A., Mechanism of inactivation of human leukocyte elastase by a chloromethyl ketone: kinetic and solvent isotope effect studies Biochemistry 25 , 5414, (1986) 摘要
  • 2. Porteu, F., et al., Human neutrophil elastase releases a ligand-binding fragment from the 75-kDa tumor necrosis factor (TNF) receptor. Comparison with the proteolytic activity responsible for shedding of TNF receptors from stimulated neutrophils J. Biol. Chem. 266 , 18846-18853, (1991)
  • Martynov, V.F., et al. J. Gen. Chem. USSR 54 , 384, (1984)

安全信息

WGK Germany3
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Enzyme - Enzyme Inhibitors
  6. D to K - Enzyme Inhibitors by Enzyme
  7. Elastase, granulocyte - D to K
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Enzymes, Inhibitors, and Substrates - Biochemicals and Reagents
  4. Enzyme Inhibitors - Enzymes, Inhibitors, and Substrates
  5. Enzyme Inhibitors by Type - Enzyme Inhibitors
  6. Substrate Analogs - Enzyme Inhibitors by Type
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Cytoskeleton and Extracellular Matrix - Cell Signaling and Neuroscience
  5. Extracellular Matrix - Cytoskeleton and Extracellular Matrix
  6. Metalloproteinase Inhibitors - Extracellular Matrix

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