Phenylethynsulfonic Acid Amide 2-苯基乙炔磺酰胺

CAS 64984-31-2 MFCD00181531

化学结构图

64984-31-2
SMILES: NS(=O)(=O)C#CC1C=CC=CC=1

化学属性

Mol. FormulaC8H7NO2S
Mol. Weight181.21
Melting Point135.0 to 139.0 deg-C

别名和识别编码

Chemical NamePhenylethynsulfonic Acid Amide
CAS Number64984-31-2
Alfabeta NamePHENYLACETYLENESULFONAMIDE 2-
MDL NumberMFCD00181531
Synonym 2-Phenyl-ethynesulfoanide PFT-μ PFT? Phenyl-ethynesulfonic Acid Amide Pifithrin-μ Pifithrin-?
PubChem Substance ID253659832
Chemical Name Translation2-苯基乙炔磺酰胺
Reaxys-RN2831436
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分类

  • Sulfur & Selenium Compounds
  • Mutagenesis Research Chemicals
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology, General Stem Cell Biology, Inhibitors, PI-PZ, Stem Cell Characterization, 干细胞生物学, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Inhibitors
  • {SNA} Apoptosis Inhibitors, Apoptosis and Cell Cycle, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzymes, Substrates, Inhibitors &, Modulators for Stem Cell Biology, General Stem Cell Biology, Inhibitors, P, Stem Cell Biology, Stem Cell Characterization

产品应用

  • A small molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

相关文献及参考

  • [2]. Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37(1):313-322.
  • [3]. Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49(2):229-234.
  • Strom, E., et al.: Nature Chemical Biology, 2, 474 (2006)
  • [1]. Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.
  • [1]. Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.
  • [2]. Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37(1):313-322.
  • [3]. Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
Storage condition 0-10°C

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Apoptosis and Cell Cycle - Cell Signaling and Neuroscience
  5. Apoptosis Inhibitors - Apoptosis and Cell Cycle
  1. Medical Research Areas
  2. Metabolism
  3. HSP  (热休克蛋白)

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