CAS 6452-73-9 MFCD00058008-Oxprenolol Hydrochloride 盐酸氧烯洛尔 TAO{mole}

Oxprenolol Hydrochloride 盐酸氧烯洛尔

CAS 6452-73-9 MFCD00058008

化学结构图

SMILES: C=CCOc1ccccc1OCC(O)CNC(C)C.Cl

化学属性

Mol. Formula	C₁₅H₂₃NO₃ • HCl
Mol. Weight	265.35 + (36.46)
Melting Point	91-93°C
Boiling Point	-
Flash Point	-

别名和识别编码

Chemical Name	Oxprenolol Hydrochloride
CAS Number	6452-73-9
Alfabeta Name	OXPRENOLOLHYDROCHLORIDE
MDL Number	-
Synonym	(+-)-1-[o-(Allyloxy)phenoxy]-3-isopropylamino-2-propanol hydrochloride 1-(2'-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(2-Allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propanol hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylamino-2-propranol-hydrochloride 1-(o-Allyloxyphenoxy)-3-isopropylaminopropan-2-ol hydrochloride 1-(o-allyloxyphenoxy)-3-isopropylamino-2-propanohydrochloride 1-(o-allyloxyphenoxy)-3-isopropylaminopropan-2-olhydrochloride 1-Isopropyl-amino-2-hydroxy-3-(O-allyloxyphenoxy)propane hydrochloride 1-Isopropylamino-3-(o-allyloxyphenoxy)-2-propanol hydrochloride 1-[(1-Methylethyl)amino]-3-[2-(2-propen-1-yloxy)phenoxy]- 1-[2-(ALLYLOXY)PHENOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL HYDROCHLORIDE 1-[2-ALLYLOXY
Chemical Name Translation	盐酸氧烯洛尔
EC Number	229-260-5
Wiswesser Line Notation	1Y1&M1YQ1OR BO2U1 &GH
LabNetwork Molecule ID	LN00150970
PubChem Substance ID	71172
InChI	InChI=1S/C15H23NO3.ClH/c1-4-9-18-14-7-5-6-8-15(14)19-11-13(17)10-16-12(2)3;/h4-8,12-13,16-17H,1,9-11H2,2-3H3;1H
Canonical SMILES	-

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产品应用

?-Adrenergic blocker. Antihypertensive, antianginal, antiarrhythmic.

安全信息

Warnings IRRITANT

Hazard Codes Xi

RTECSUA5277000

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 90 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Cardiac - arrhythmias (including changes in conduction)
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   1,552,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3131,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 940 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,164,1968

TYPE OF TEST            : LD90 - Lethal Dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Cardiac - pulse rate
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 21 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFE

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1400 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 336 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : female 8-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 7,3169,1973

Hazard statements

H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P301+P310
P301+P312
P301+P316
P301+P317
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Storage condition -20°C -20°C, Inert atmosphere

其他信息

急性毒性:口服-大鼠LD50: 900 毫克/公斤
毒性分级:中毒
MOL 文件:6452-73-9.mol
可燃性危险特性:可燃;燃烧产生有毒氮氧化物和氯化氢烟雾
Hazard Note:Irritant
储运特性:库房通风低温干燥; 与食品原料分开存放
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
类别:有毒物品