CAS 64-77-7 MFCD00027169-Tolbutamide 甲苯磺丁脲 TAO{mole}

Tolbutamide 甲苯磺丁脲

CAS 64-77-7 MFCD00027169

化学结构图

SMILES: CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1

化学属性

Mol. Formula	C12H18N2O3S
Mol. Weight	270
Melting Point	128-130
TSCA	Yes

别名和识别编码

Chemical Name	Tolbutamide
MDL Number	MFCD00027169
CAS Number	64-77-7
Synonym	Orezan Orabet 1-p-Toluenesulfonyl-3-butylurea Orinaz 1-丁基-3-(4-甲苯磺酰基)脲 N-[(Butylamino)carbonyl]-4-methylbenzenesulfonamide Artosin Tolbusal Butamide Diaben Tolbutamidum Oralin Diabetol N-4-Methylbenzolsulfonyl-N-butylurea 1-n-Butyl-3-(p-tolylsulfonyl)urea Willbutamide 3-(p-Tolyl-4-sulfonyl)-1-butylurea Diabetamid 1-Butyl-3-tosylurea 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]-amino]sulfonyl]phenyl]-ethyl]-2-methoxybenzamide; Glibenclamide Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl- Butamid HLS 831 SK-Tolbutamide N-(p-Tolylsulfonyl)-N'-butylcarbamide Orinase Arkozal Mobenol Toluina D 860 Dolipol Tolylsulfonylbutylurea 1-Butyl-3-(p-methylphenylsulfonyl)urea Aglicid Tolbutamid N-Butyl-N'-p-toluenesulfonylurea 1-Butyl-3-(p-tolylsulfonyl)urea 甲苯磺丁脲, 98% N-Butyl-N'-toluene-p-sulfonylurea Rastinon Tolumid N-(Sulfonyl-p-methylbenzene)-N'-n-butylurea 甲苯磺丁脲 Drabet Oterben Beglucin Diabuton Ipoglicone NCI-C01763 Arcosal Tolbutamide Artozin N-n-Butyl-N'-tosylurea Toluvan
PubChem Substance ID	354335795
Beilstein Registry Number	1984428
EC Number	200-594-3
Merck Number	9507
Chemical Name Translation	甲苯磺丁脲
Wiswesser Line Notation	4MVMSWR D1
LabNetwork Molecule ID	LN00235930
Reaxys-RN	1984428
InChI	InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

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安全信息

RTECSYS4550000

WGK Germany2

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Safety Statements

S24 Avoid contact with skin 避免皮肤接触；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S37 Wear suitable gloves 戴适当手套；

Risk Statements

R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

GHS Symbol

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRZKAP Farmatsevtichnii Zhurnal (Kiev).  (V/O Mezhdunarodnaya Kniga, 113095
   Moscow, USSR) V.3-    1930-  Volume(issue)/page/year: (5),26,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
   Endocrine - hypoglycemia
REFERENCE :
   ATXKA8 Archiv fuer Toxikologie.  (Berlin, Fed. Rep. Ger.)  V.15-31, 1954-74.
    For publisher information, see ARTODN.  Volume(issue)/page/year:
   23,153,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 860 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 12,268,1957

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 770 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PMDCAY Progress in Medical Chemistry.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1961- Volume(issue)/page/year:
   1,187,1961

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2860 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (El

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 mmol/L
REFERENCE :
   BZARAZ Biologicheskii Zhurnal Armenii.  Biological Journal of Armenia. (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.19-    1966-
   Volume(issue)/page/year: 33,960,1980

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 28600 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,349,1980

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 2 gm/kg/24H
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 34,153,1986

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 28600 ug/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 77,349,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 200 mmol/L
REFERENCE :
   BZARAZ Biologicheskii Zhurnal Armenii.  Biological Journal of Armenia. (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.19-    1966-
   Volume(issue)/page/year

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   PROEAS Problemy Endokrinologii.  Problems of Endocrinology.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-6, 1936-41; 13-    1967-
   Volume(issue)/page/year: 14,89,1968

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 2600 mg/kg
SEX/DURATION            : female 1-37 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   77,457,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 1800 mg/kg
SEX/DURATION            : female 26-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   2,187,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1650 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   METAAJ Metabolism, C

Hazard statements

H303 May be harmfully swallowed 吞食可能有害

Signal word