CAS 64-43-7 MFCD00083230-Amytal sodium 阿米妥钠 TAO{mole}

Amytal sodium 阿米妥钠

CAS 64-43-7 MFCD00083230

化学结构图

SMILES: CCC1(CCC(C)C)C(=O)N=C([O-])NC1=O.[Na+]

化学属性

Mol. Formula	C11H18N2O3.Na
Mol. Weight	249.30
Appearance	白色粉末。极易溶于水，能溶于乙醇，几乎不溶于乙醚或氯仿。

别名和识别编码

Chemical Name	Barbituric acid, 5-ethyl-5-isopentyl-, sodium salt
Synonym	Sodium ethylisoamylbarbiturate drinamyl Dorminal 5-Ethyl-5-(3-methylbutyl)-2,4,6-(1H,3H,5H)-pyrimidinetrione sodium salt 阿米妥钠 5-乙基-5-异戊巴比妥酸阿米妥 Sodium amytal Inmetal 5-ethyl-5- AMOBARBITAL SODIUM SALT {Chemi 5-乙基-5-异戊基巴比妥钠 5-乙基-5-异戊基-2,4,6(1H,3H,5H)-嘧啶三酮一钠盐 t-Barb amsebarb 5-ethyl-5-isopentyl-barbituricacisodiumderiv. Dusotal sodiumamylobarbitone 5-ethyl-5-(3-methylbutyl)-2,4,6-(1h,3h,5h)-pyrimidinetrionesodiumsalt Amobarbital sodium 异戊巴比妥纳 Sodium amobarbital 5-ETHYL-5-ISOAMYLBARBITURIC ACID SODIUM SALT Sodium 5-ethyl-5-(3-methylbutyl)-4,6-dioxo-1H-p AMOBARBITAL SODIUM Drinamyl 异戊巴比妥钠盐 5-Ethyl-5-(3-methylbutyl)barbituric acid sodium derivative Sodium amylobarbitone sodiumamobarbital 5-isoamyl-5-ethylbarbituricacid,sodiumderiv amobarbital sodium 5-Ethyl-5-isopentylbarbituric acid sodium salt Barbituric acid, 5-ethyl-5-isopentyl-, sodium deriv. Barbamyl inmetal Amytal sodium dusotal Natrium-5,5-äthyl-isoamylbarbi 041104限制性化学品禁止出口 5-ethyl-5-isopentylbarbituricacidsodiumsalt Amsebarb amylobarbitone,sodiumderiv amytalsodium 5-乙基-5-异戊基巴比妥酸钠异戊巴比妥钠 alitinal 5-Isoamyl-5-ethylbarbituric acid, sodium deriv 5-ethyl-5-isopentyl-barbituricacisodiumsalt Alitinal Amylobarbitone, sodium deriv Sodium barbamyl Sodium iso
PubChem Substance ID	24890864
EC Number	200-584-9
MDL Number	MFCD00083230
CAS Number	64-43-7
Chemical Name Translation	阿米妥钠
Wiswesser Line Notation	T6VMVMV FHJ FY1&1 F2 &-NA-

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安全信息

GHS Symbol

WGK Germany3

Hazard statements

H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Precautionary statements

P301+P310

Signal word Danger

RTECSCQ5250000

Packing GroupIII

Hazard Codes Xn

Hazard Class6.1(b)

Storage condition 2-8°C

UN Number UN 2811 6.1/PG 3

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

Restrict 精神药品

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 170 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPHAA3 Journal of the American Pharmaceutical Association.  (Washington, DC)
    V.1-28, 1912-39; New series: V.1-17, 1961-77. Volume(issue)/page/year:
   26,1248,1937

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 505 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 14,845,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,265,1946

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Behavioral - general anesthetic
   Behavioral - tremor
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 44,152,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

其他信息

上游原料:异戊巴比妥 --> 氢氧化钠-乙醇溶液
方法一:由异戊巴比妥（见02870）成盐而得。先配制好氢氧化钠乙醇溶液，将异戊巴比妥溶解在氢氧化钠乙醇液中，再加入活性炭，在室温搅拌下脱色半小时。滤去活性炭，滤液减压蒸馏回收乙醇。加入丙酮使异戊巴比胺纳结晶析出。过滤，减压干燥，得产品，收率为70%。
储运特性:库房通风低温干燥
毒性分级:高毒
急性毒性:口服-大鼠 LD50: 275 毫克/公斤; 口服-小鼠 LD50: 505 毫克/公斤
Sigma Aldrich:64-43-7(sigmaaldrich)
用途一:该品为中时间作用的催眠药。
MOL 文件:64-43-7.mol
阿米妥钠价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 69020234 异戊巴比妥钠盐 25g 80元
灭火剂:干粉、泡沫、砂土、二氧化碳,雾状水
可燃性危险特性:可然; 燃烧产生有毒氮氧化物和氧化钠烟雾
类别:有毒物品