NMDA N-甲基-D-天门冬氨酸
CAS 6384-92-5 MFCD00004226
化学结构图
SMILES: CN[C@@H](CC(O)=O)C(O)=O |&1:2|
化学属性
| Mol. Formula | C5H9NO4 |
|---|---|
| Mol. Weight | 147 |
| Melting Point | 189-190 |
| Solubility | DMSO 5 mg/mL Water 30 mg/mL Ethanol <1 mg/mL |
| TSCA | No |
别名和识别编码
| Chemical Name | NMDA |
|---|---|
| MDL Number | MFCD00004226 |
| CAS Number | 6384-92-5 |
| Synonym | N-Methyl-D-asparaginic Acid Hydrate N-甲基-D-天冬氨酸 NMDA |
| Beilstein Registry Number | 4(3)1522 |
| PubChem Substance ID | 87573315 |
| Merck Number | 6662 |
| Chemical Name Translation | N-甲基-D-天门冬氨酸 |
| Reaxys-RN | 1724431 |
| LabNetwork Molecule ID | LN00196057 |
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分类
- {SNA} Bioactive Small Molecules, Cell Signaling and Neuroscience, Excitatory Amino Acids, M, NMDA Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 细胞生物学
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Excitatory Amino Acids, M, NMDA Agonists, Neuroscience, Neurotransmission, Neurotransmitters
- {SNA} Excitatory Amino Acids, NMDA Agonists, Neuroscience, Neurotransmission, Neurotransmitters, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Amino Acids,
相关文献及参考
- [2]. Yoneda Y, et al. Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal. Brain Res. 1987 Mar 17;406(1-2):24-31.
- [3]. Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic pain through N-methyl-D-aspartate receptor activation. Neuroreport. 2017 May 24;28(8):444-450.
- [1]. Xia JD, et al. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus. Andrology. 2016 Nov 16.
- [1]. Xia JD, et al. Centrally mediated ejaculatory response via sympathetic outflow in rats: role of N-methyl-D-aspartic acid receptors in paraventricular nucleus. Andrology. 2016 Nov 16.
- [2]. Yoneda Y, et al. Enhancement of [3H]glutamate binding by N-methyl-D-aspartic acid in rat adrenal. Brain Res. 1987 Mar 17;406(1-2):24-31.
- [3]. Jiang L, et al. Decrease of growth and differentiation factor 10 contributes to neuropathic
安全信息
GHS Symbol
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 137 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 269,573,1994
其他信息
- N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel intimately involved in spatial learning and memory, and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.
- N-甲基-D-天冬氨酸
