Desonide, 98%, reference material 地索奈德

CAS 638-94-8 MFCD00866151

化学结构图

638-94-8
SMILES: CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4C(O)CC3(C)C2(C(=O)CO)O1

化学属性

Mol. FormulaC24H32O6
Mol. Weight416.51
SolubilitySoluble in DMSO and DMF
Melting Point274-275°C
Boiling Point580.1°C at 760 mmHg
Flash Point196.9°C
Density1.3

别名和识别编码

Chemical NameDesonide, 98%, reference material
CAS Number638-94-8
Synonym Desonide {LY} Desonide Desowen Locapred Locatop Prednacinolone Tridesilon Tridésonit {} {LY} Desonide {} {} {LY} Desonide {} {} {} {LY} Desonide {} {} {} {} {LY} Desonide {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Desonide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00866151
EC Number211-351-6
Chemical Name Translation地索奈德
Wiswesser Line NotationT F5 E5 B666 GO IO RV AHTTTT&J A1 CQ E1 FV1Q H1 H1
LabNetwork Molecule IDLN01265776
Reaxys-RN56987
Merck Number2928
PubChem Substance ID5311066
InChIInChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1
Canonical SMILESC[C@@]12[C@@]3(C(CO)=O)[C@@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O
Beilstein Registry Number56987
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分类

  • Chiral Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Steroids

产品应用

  • An antiinflammatory compound.

相关文献及参考

  • [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.
  • [3]. Parish, D. and N. Scheinfeld, Desonide foam: a review. Drugs Today (Barc), 2008. 44(1): p. 55-62.
  • Phillips, et al.: Toxicol. Appl. Pharmacol., 20, 522 (1971),
  • Sanen, F.J., et al.: Int. J. Clin. Pharmacol. Biopharm., 12, 174 (1975),
  • [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.
  • [1]. Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17(7): p. 1097-104.
  • [2]. Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-cont

安全信息

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
RTECSTU2800000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 93 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   20,522,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3710 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 20,111,1970

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H303 May be harmfully swallowed 吞食可能有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H332 Harmful if inhaled 吸入有害
  • H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官
Signal word Warning
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P317
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P362+P364
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
GHS Symbol

其他信息

  • MOL 文件:638-94-8.mol
  • MSDS 信息:Desonide(638-94-8).msds
  • Desonide是一种低效的外用皮质类固醇激素。

系列性分类


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