N,N-dipropylnitrous amide N、N-二丙基亚硝酰胺

CAS 621-64-7 MFCD00013891

化学结构图

621-64-7
SMILES: CCCN(CCC)N=O

化学属性

Mol. FormulaC6H14N2O
Mol. Weight130
Refractive index1.4410 to 1.4450
Density0.92
Boiling Point113°C/40mmHg(lit.)
Flash Point10 °C
Solubility微溶于水。

别名和识别编码

Chemical NameN,N-dipropylnitrous amide
CAS Number621-64-7
Synonym N,N-Dipropylnitrosamine N-亚硝基-n-丙基-1-丙胺 n-nitroso-n-propyl-1-propanamin DIPROPYLNITROSAMINE dipropyl-nitroso-amine 二丙基亚硝胺 N-nitroso-N-propyl-1-propanamine Dipropylamine, N-nitroso- N-NITROSODIPROPYLAMINE Di-n-propylnitrosoamine DPNA N-二丙基亚硝胺 Di-N-propylnitrosamine N-Propanamine,N-propyl-N-nitroso- N-亚硝基二丙胺 n-nitroso-dipropylamin n,n-di-n-propylnitrosamine N-Nitrosodipropylamine n-nitroso-n-propyl-propanamin N-NITROSODI-N-PROPYLAMINE N-Nitroso-n-propyl-1-propanamine n-nitroso-n-di-propylamin N-亞硝二丙胺 N-Nitroso-N-propyl-1-aminopropan 二丙亞硝胺 二正丙基亚硝胺 N-二丙基亚硝胺,二正丙基亚硝胺 N-nitrosodi-n-propylamine N-亚硝基二正丙胺 Di-n-propylnitrosamine N-Nitroso-N-di-n-propylamine N-Propanamine, N-propyl-N-nitroso- N-二正丙基亚硝胺 Propylamine, N-nitroso-N-di- 2-Oxo-1,1-dipropylhydrazine NDPA Nitrosodipropylamine Dipropylnitrosamine N-nitroso-N-dipropylamine nitroso-dipropyl-amine RCRA waste number U111 N-Nitroso-N-propyl-1-propanamine 1-Propanamine, N-nitroso-N-propyl- N-Nitrosodi-n-propylamine DPN N-nitrosodipropylamine Propanamine, N-nitroso-N-propyl- NSC 133 n-亚硝基正丙胺
MDL NumberMFCD00013891
PubChem Substance ID87573779
EC Number210-698-0
Reaxys-RN1752621
Beilstein Registry Number4(3)264
Chemical Name TranslationN、N-二丙基亚硝酰胺
Wiswesser Line NotationONN3&3
LabNetwork Molecule IDLN01300498
InChIInChI=1S/C6H14N2O/c1-3-5-8(7-9)6-4-2/h3-6H2,1-2H3
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分类

  • Aliphatics, Alpha Sort, Alphabetic, Amines, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Environmental Standards, N, N-O, NA - NI, Volatiles/ Semivolatiles
  • {uni_hamburg} no charge; 1fragment

产品应用

  • 用于医药和食品分析研究。

相关文献及参考

  • Short: IV/20C
  • Short: EINECS
  • Beilstein:4(3)264
  • Short: IV/16

安全信息

Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H331 Toxic if inhaled 吸入中毒
  • H350 May cause cancer 可能致癌
  • H370 Causes damage to organs 导致器官损伤
RTECSJL9700000
WGK Germany3
GHS Symbol
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P301+P310
  • P301+P312+P330
  • P308+P311
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard Codes T,N,F F,T
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
UN Number 2810 3082
Packing GroupIII
Hazard Class9
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
  • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
Storage condition 储存温度 2-8℃ 2-8°C 密封于4℃保存。
Risk Statements
  • R11 Highly flammable 非常易燃
  • R22 Harmful if swallowed 吞咽有害
  • R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入,皮肤接触及吞食都有毒
  • R45 May cause cancer 可能致癌
  • R51/53
  • R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性:吸入,皮肤接触和吞食都会产生十分严重的不可逆危险
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1516 mg/kg/44W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Gastrointestinal - tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 90,253,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 660 mg/kg/60W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Liver - tumors
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   19,207,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1760 mg/kg/27W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Gastrointestinal - tumors
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 90,141,1977

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1056 mg/kg/30W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Liver - tumors
REFERENCE :
   CALEDQ Cancer

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 689 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie.  (Berlin,
   Fed. Rep. Ger.)  V.76-92, 1971-78.  For publisher information, see JCROD7.
   Volume(issue)/page/year: 90,253,1977

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : >400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   31,361,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 480 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   69,103,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   51,1019,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Vo

TYPE OF TEST            : DNA damage
TEST SYSTEM

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TCMUE9 Topics in Chemical Mutagenesis.  (Plenum Pub. Corp., 233 Spring
   Street, New York, NY 10013) V.1-    1984-  Volume(issue)/page/year:
   1,91,1984

TYPE OF TEST            : DNA inhibition
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 20 gm/kg
REFERENCE :
   ARGEAR Archiv fuer Geschwulstforschung.  (VEB Verlag Volk und Gesundheit
   Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.)  V.1-    1949-
   Volume(issue)/page/year: 51,605,1981

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 310 ug/kg
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Liver
DOSE/DURATION           : 1800 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,4144,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Kidney
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 368,41,1996

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其他信息

  • 二丙基亚硝胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0444 N-亚硝基二丙胺 N-Nitrosodipropylamine 5G 1130元 2014/06/02 N0444 N-亚硝基二丙胺 N-Nitrosodipropylamine 25G 3010元
  • 外观性质:黄色透明液体。
  • RTECS号:JL9700000
  • 能与乙醇、乙醚混溶,微溶于水。有致癌的可能性。
  • MOL 文件:621-64-7.mol
  • PackingGroup:III
  • HazardClass:6.1(b)

系列性分类


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