4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride 4-氨基-N-[2-(二乙基氨基)乙基]苯甲酰胺盐酸盐

CAS 614-39-1 MFCD00012998

化学结构图

614-39-1
SMILES: CCN(CC)CCNC(=O)c1ccc(N)cc1.Cl

化学属性

Mol. FormulaC13H21N3O.ClH
Mol. Weight271.83
Melting Point155-165
Solubility可溶
Appearance 白色或淡黄色结晶性粉末。熔点165-169℃。易溶于水，溶于乙醇，微溶于氯仿，极微溶于乙醚或苯。无臭，有引湿性。

别名和识别编码

Chemical Name4-Amino-N-[2-(diethylamino)ethyl]benzamide monohydrochloride
Alfabeta NameAMINODIETHYLAMINOETHYLBENZAMIDEHYDROCHLORIDE N42[]()----
MDL NumberMFCD00012998
CAS Number614-39-1
Synonym 奴佛卡因胺 procamidehydrochloride p-Amino-N-(2-(diethylamino)ethyl)benzamide hydrochloride promidehydrochloride procan-srhydrochloride 4-AMINO-N-[2'-(DIETHYLAMINO)ETHYL]BENZAMIDE HCL p-amino-n-(2-(diethylamino)ethyl)-benzamidhydrochloride 普鲁卡因盐酸盐 Pronestyl hydrochloride PROCAINAMIDE HYDROCHLORIDE 4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride 4-amino-n-[2-(diethylamino)ethyl]-benzamidmonohydrochloride Procan-SR hydrochloride TIMTEC-BB SBB001067 盐酸普鲁卡胺 PROCAINAMIDE HCL N-(2-DIETHYLAMINOETHYL)-4-AMINOBENZAMIDE HYDROCHLORIDE procardylhydrochloride PROCAINE AMIDE HYDROCHLORIDE Procamide hydrochloride 4-AMINOBENZOIC ACID 2-DIETHYLAMINOETHYLAMIDE HYDROCHLORIDE Promide hydrochloride amidoprocain p-amino-n-(2-(diethylamino)ethyl)benzamidehydrochloride Amidoprocain Procainamide hydrochloride 丙酰胺盐酸盐 4-AMINO-N-(2-DIETHYLAMINOETHYL)BENZAMIDE HYDROCHLORIDE Procapan hydrochloride 4-Amino-N-(2-(diethylamino)ethyl)benzamide monohydrochloride 4-amino-n-(2-(diethylamino)ethyl)benzamidemonohydrochloride procapanhydrochloride 普鲁卡因酰胺 PROCAINAMIDE Procaine amide hydrochloride 普鲁卡因胺盐酸盐 Supicane amide hydrochloride 4-Amino-N-(2-diethylaminoethyl)benzamide hydrochloride 4-Aminobenzoic acid 2-diethylaminoethylamide novocamidhydrochloride N-[(2-二乙氨基)乙基]-4-氨基苯甲酰胺盐酸盐 盐酸普鲁卡因胺 Procardyl hydrochloride Novocamid hydrochloride
PubChem Substance ID66068
Beilstein Registry Number3729517
EC Number210-381-7
Chemical Name Translation4-氨基-N-[2-(二乙基氨基)乙基]苯甲酰胺盐酸盐
Merck Number13,7845
Wiswesser Line NotationZR DVM2N2&2 &GH
LabNetwork Molecule IDLN02219974
InChIInChI=1S/C13H21N3O.ClH/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11;/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);1H
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分类

  • {SNA} Antitumor Agents, Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Re
  • {SNA} Analytical Standards,
  • {SNA} Analytical Standards, Chromatography, Pharmaceutical Standards, Pharmacopeia Standards, USP Standards, USP Standards P - R, 分析/色谱
  • {SNA} Ana
  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, Pharmaceutical Secondary Standards, Pharmaceutical Standards
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards P - R, Pharmaceutical Standards, Pharmacopeia Standards, 分析/色谱
  • {SNA} Analytical Sta
  • {SNA} Analytical Standards, Analytical/Chromatography,

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSCV2295000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Signal word
Hazard Codes Xn
Safety Statements
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 200 mg/kg/4W-I
TOXIC EFFECTS :
   Blood - thrombocytopenia
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 18,1127,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1509 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (2),28,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 10 mg/kg/6M-C
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
REFERENCE :
   CPHADV Clinical Pharmacy.  (American Soc

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 857 mg/kg/60D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   AHJOA2 American Heart Journal.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63146) V.1-    1925-  Volume(issue)/page/year:
   105,1035,1983

其他信息

  • 上游原料:乙基苯 --> 4-硝基苯甲酰氯 --> 苯甲酰胺 --> 二乙氨基乙胺 --> 普鲁卡因胺
  • Acros Organics:普鲁卡因胺盐酸盐 Procainamide hydrochloride, 99%(614-39-1)
  • 方法一:对硝基苯甲酰氯与二乙氨基乙胺缩合，得到对硝基-N-（2-二乙氨基乙基）苯甲酰胺（硝基卡因胺），再经催化氢化生成普鲁卡因胺，然后用盐酸成盐即为本品。
  • MOL 文件:614-39-1.mol
  • Sigma Aldrich:614-39-1(sigmaaldrich)
  • 盐酸普鲁卡因胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 207300250 盐酸普鲁卡因胺 Procainamide hydrochloride 99% 25 GR 382元 2010/06/21 207301000 盐酸普鲁卡因胺 Procainamide hydrochloride 99% 100 GR 1451元
  • 敏感性:Light Sensitive/Air Sensitive
  • 用途一:抗心律失常。与奎尼丁相似，同属典型膜稳定剂。适用于室性心律失常，也可用于房性心律失常和心肌梗塞患者预防心律失常等。

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Gene Regulation and Expression - Cell Signaling and Neuroscience
  5. DNA-RNA Transcription Regulators - Gene Regulation and Expression
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. P - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Amides - Carbonyl Compounds
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Ion Channels - Cell Signaling and Neuroscience
  5. Voltage-gated Ion Channels - Ion Channels
  6. Monovalent Ion Channels - Voltage-gated Ion Channels
  7. Sodium Channel Modulators - Monovalent Ion Channels
  8. Other Sodium Channel Modulators - Sodium Channel Modulators
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Aldehydes
  6. C9
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Gene Regulation and Expression
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Cell Signaling Enzymes
  5. Xenobiotics and Drug Metabolism
  6. Inhibitors

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