Methoxamine Hydrochloride 2-氨基-1-(2,5-二甲氧基苯基)丙-1-醇盐酸盐

CAS 61-16-5 MFCD00058607

化学结构图

61-16-5
SMILES:

化学属性

Mol. FormulaC11H17NO3· HCl
Mol. Weight247.72

别名和识别编码

Chemical NameMethoxamine Hydrochloride
Synonym 1-(2,5-Dimethoxyphenyl)-2-aminopropanol 2-Amino-1-(2,5-dimethoxyphenyl)-1-propanol hydrochloride 2-Amino-1-hydroxy-1-(2,5-dimethoxyphenyl)propane hydrochloride METHOXAMINE HCL Methoxamine hydrochloride Vasoxine Vasoxine hydrochloride alpha-(1-aminoethyl)-2,5-dimethoxy-benzenemethanohydrochloride alpha-(1-aminoethyl)-2,5-dimethoxy-benzylalcohohydrochloride alpha-(alpha-aminoethyl)-2,5-dimethoxybenzylalcoholhydrochloride beta-(2,5-Dimethoxyphenyl)-beta-hydroxyisopropylamine hydrochloride beta-(2,5-dimethoxyphenyl)-beta-hydroxyisopropylaminehydrochloride beta-Hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylamine hydrochloride beta-hydroxy-beta-(2,5-dimethoxyphenyl)-isopropylaminehydrochloride vasoxinehydrochloride {} {Chemi 凡索昔 盐酸甲氧胺
MDL NumberMFCD00058607
CAS Number61-16-5
PubChem Substance ID24277785
EC Number200-499-7
Chemical Name Translation2-氨基-1-(2,5-二甲氧基苯基)丙-1-醇盐酸盐
Wiswesser Line NotationZY1&YQR BO1 EO1 &GH
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分类

  • {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, M, Membrane Protein Biology Tools, Neuroscience,

安全信息

WGK Germany3
RTECSDN4025000
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Storage condition 2-8°C
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 135 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   27ZIAQ "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes,
   C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973
   Volume(issue)/page/year: -,160,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5030 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   EJPHAZ European Journal of Pharmacology.  (Elsevier Science Pub. B.V., POB
   211, 1000 AE Amsterdam, Netherlands)  V.1-    1967- Volume(issue)/page/year:
   9,289,1970

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 92,283,1948

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intratesticular
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : male 21 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 58,19,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 400 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Fertility - male fertility index (e.g. # males impregnating
   females per # males exposed to fertile nonpregnant females)
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   JRPFA4 Journal of Reproduction and Fertility.  (Biochemical Soc. Book Depot,
   POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1960-
   Volume(issue)/page/year: 58,19,1980

其他信息

  • Sigma Aldrich:61-16-5(sigmaaldrich)
  • MOL 文件:61-16-5.mol

系列性分类


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