• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} B, Bioactive Small Molecule Alphabetical Index, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
• Heterocycles
• Pharmaceuticals
• Aromatics
• {SNA} B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Drug and Xenobiotic Metabolism, Multi-Drug Resistance and Drug Metabolism, Substrates, Inducers, Inhibitors
• Intermediates & Fine Chemicals,

产品应用

• A ?-Adrenergic blocker with peripheral vasodilating activity. Antianginal; antihypertensive.

相关文献及参考

• [2]. Jie Cai, et al. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9.
• [3]. Sarah M Glass, et al. CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712. Drug Metab Dispos. 2018 Aug;46(8):1106-1117.
• [4]. T Prueksaritanont, et al. (+)-bufuralol 1'-hydroxylation activity in human and rhesus monkey intestine and liver. Biochem Pharmacol. 1995 Oct 26;50(9):1521-5.
• Francis, R.J., et al.: Eur. J. Clin. Pharmacol., 23, 529 (1982),
• Pfisterer, M., et al.: J. Cardiovasc. Pharmacol., 6, 417 (1984),
• [1]. T H Pringle
• [1]. T H Pringle, et al. Pharmacodynamic and pharmacokinetic studies on bufuralol in man. Br J Clin Pharmacol. 1986 Nov;22(5):527-34.

安全信息