Gestodene 孕二烯酮
CAS 60282-87-3 MFCD00867858
化学结构图
SMILES: CC[C@@]12CC[C@H]3[C@@H]4CCC(=O)C=C4CC[C@@H]3[C@H]1CC[C@]2(O)C#C |&1:2,5,6,15,16,19|
化学属性
| Mol. Formula | C21H26O2 |
|---|---|
| Mol. Weight | 310 |
别名和识别编码
| Chemical Name | Gestodene |
|---|---|
| CAS Number | 60282-87-3 |
| Synonym | (17)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one, Gestinol, SHB 331, WL 70 (17?)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one (17α)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one Gestinol SHB 331 WL 70 (17α)-13-Ethyl-17-hydroxy-18,19-Dinorpregna-4,15-dien-20-yn-3-one, Gestinol, SHB 331, WL 70 17-alpha-Ethinyl-13-ethyl-17-beta-hydroxy-4,15-gonadien-3-one SH B 331 SHB 331 WL 70 |
| MDL Number | MFCD00867858 |
| EC Number | 262-145-8 |
| Chemical Name Translation | 孕二烯酮 |
| Beilstein Registry Number | 4237181 |
| PubChem Substance ID | 329825299 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, New Products, Progesterone, Steroid Hormones
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Progesterone, Steroid Hormones
- {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, G, Hormones, Progesterone, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Orally active gestogen with progesterone-like profile of activity. Used in combination with estrogen as oral contraceptive.
相关文献及参考
- Duesterberg, B., et al.: Contraception, 24, 673 (1981),
- Duesterberg, B., et al.: Seroids, 43, 43 (1984),
- Losert, W., et al.: Arzneim.-Forsch., 35, 459 (1985),
- Seeger, H., et al., The effect of progesterone and synthetic progestins on serum- and estradiol-stimulated proliferation of human breast cancer cells. Horm. Metab. Res. 35 , 76-80, (2003)
- Iqbal, M.J., and Colletta, A.A., Characterisation of gestodene binding to the oestrogen receptor in human malignant breast tissue. Anticancer Res. 7 , 45-48, (1987)
- Iqbal, J.J., et al., Differences in oestrogen receptors in malignant and normal breast tissue as identified by the binding of a new synthetic progestogen. Br. J. Cancer 54 , 447-452, (1986)
安全信息
GHS Symbol
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R62 Possible risk of impaired fertility 有削弱生殖能力的危险
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 12 ug/kg SEX/DURATION : female 1 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - other measures of fertility REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 35,459,1985
