CAS 60-33-3 MFCD00064241-Linoleic acid 亚油酸 TAO{mole}

Linoleic acid 亚油酸

CAS 60-33-3 MFCD00064241

化学结构图

SMILES: CCCCCC=CCC=CCCCCCCCC(=O)O

化学属性

Mol. Formula	C18H32O2
Mol. Weight	280.45
Refractive index	1.4680 to 1.4720
Boiling Point	229-230 °C at 16 mmHg
Density	0.902
Melting Point	-5 °C
Flash Point	>110°(230°F)
TSCA	Yes
Solubility	不溶
Stability	对光敏感
Appearance	liquid

别名和识别编码

Chemical Name	Linoleic acid
Synonym	Linoleic acid {LY} Linoleic acid {} {LY} Linoleic acid {} {} {LY} Linoleic acid {} {} {} {LY} Linoleic acid {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Linoleic acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number	60-33-3
PubChem Substance ID	87572020
EC Number	200-470-9
Beilstein Registry Number	1727101
MDL Number	MFCD00064241
Merck Number	5505
Chemical Name Translation	亚油酸
Reaxys-RN	1727101
InChIKey	OYHQOLUKZRVURQ-HZJYTTRNSA-N
Wiswesser Line Notation	QV8U3U6
LabNetwork Molecule ID	LN00202355
InChI	InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
Canonical SMILES	CCCCC/C=C\C/C=C\CCCCCCCC(O)=O

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分类

{SNA} Acid, All Alphabetically Sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Applications, Bioactive Small Molecules, Biochemicals and Reagents, Chromatography, Fats (fatty acids, FAMEs, glycerides), Edible Oils, Sterols, Fatty Acids, Fatty Acids and conjugates, Fatty Acyls, Flavors and Fragrances, Food & Beverage Analysis, Food & Beverage Standards, Free Fatty Acids, Functional Foods, G-L, Individual Analytes, L, Lipid Analytical Standards, Lipids, Lipids - FA/FAME/Oils/Sterols,
{SNA} Bi
{SNA} Fatty Acids and conjugates

安全信息

WGK Germany1

Personal Protective Equipment Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves, half-mask respirator (EU), half-mask respirator (US), multi-purpose combination respirator cartridge (US) Eyeshields, Gloves

Hazard Codes Xi

RTECSRF9990000

Storage condition -20°C, protect from light, stored under nitrogen {LY} -20°C, protect from light, stored under nitrogen -20℃避光保存 0-10 0-10°C 2-8°C 2-8℃避光保存 Air Sensitive {} {LY} -20°C, protect from light, stored under nitrogen {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, protect from light, stored

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；

Signal word Warning

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P302+P352
P305+P351+P338
P305+P351+P338+P337+P313
P332+P313

Hazard statements

H316 Causes mild skin irritation 会轻微的刺激皮肤

GHS Symbol

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 104,793,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USXXAM United States Patent Document.  (U.S. Patent Office, Box 9,
   Washington, DC 20231)  Volume(issue)/page/year: #3728459

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >50 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 4,327,1970

其他信息

用途三:营养增补剂，增香剂。
用途四:亚油酸是人和动物营养中必需和脂肪酸。动植物都有去饱和酶，能使饱和脂肪酸脱氢，生成油酸一类的具有一个双键的不饱和脂肪酸，但只有植物细胞具备使油酸进一步脱氢成亚油酸的能力。亚油酸是合成动物前列腺素的前体。缺乏亚油酸的亚麻酸等脂肪酸，会使动物发育不良，皮肤和肾损伤，不育等。亚油酸能与胆固醇结合成酯，并可进而促使胆固醇降解为胆酸，然后排出体外，亦有降低甘油三酯作用。在医药上用于预防和治疗动脉粥样硬化药物（如益寿宁、脉通等）的原料。在工业方面，亚油酸用于油漆、油墨的生产及制取酰胺、聚酯、聚脲等。亚油酸钠盐或钾盐是肥皂的成分之一，并可用作乳化剂等表面活性剂。亚油酸无毒。
使用限量:GMP(FDA§182．5065，2000)。
方法二:由亚麻子油等经水解、分馏而得。
亚油酸价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 K6223001 亚油酸标准液（+4℃） 5ml 480元 2011/04/16 L0053 亚油酸 Linoleic Acid 25ML 418元 2011/04/16 L005
上游原料:硬脂酸 --> 植物油 --> 棕榈酸 --> 大豆油 --> 大豆 --> 菜籽油 --> 紫红 --> 猪油 --> 花生油 --> 玉米油 --> 牛油 --> 酚酞指示剂 --> 大豆油脂肪酸 --> 亚麻子油
所属类别一:生物化
敏感性:Air Sensitive
食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称允许使用该种添加剂的食品中文名称添加剂功能最大允许使用量（g/kg）最大允许残留量（g/kg）亚油酸食品食品用香料用于配制香精的各香料成分不得超过在GB 2760中的最大允许使用量和最大允许残留量
方法三:亚油酸以甘油酯的形式与其他脂肪酸一起存在于动物脂肪中。动物脂肪中的含量一般较低，如牛油1.8%，猪油为6%；若干种植物油中含量较高，如花生油为26%，菜油为15.8%，而大豆所含脂肪酸则以亚油酸为主。大豆油脂肪酸一般组成如下：油酸 15-33%亚油酸 53-56%亚麻酸 5-9%棕榈酸 7-11%硬脂酸 2-6%C20以上酸 0.3-3%大豆油在精炼过程中约有5-10%的油脚和皂脚成生。豆油皂脚中有一半是有用的脂肪酸，而皂脚中脂肪酸
方法一:方法一、以玉米油为原料亚油酸粗制品的制备量取澄清的玉米油，逐渐加入200g/L氢
Sigma Aldrich:60-33-3(sigmaaldrich)
所属类别二:食品添加剂: 营养强化剂（营养增补: 其他营养增补剂
MOL 文件:60-33-3.mol
用途二:降血脂药，用于治疗与预防动脉粥样硬化症。一般无副作用。长期服用可出现恶心、呕吐、腹泻等胃肠道反应，继续给药可逐渐消失。
参考质量标准:指标 FCC,1996 FAO/WHO,1998 含量(C18:2;无水基计；GT-10-4) ≥60.0% ≥60.0% 酸值(OT-4-1) 196~202 - n D 20 - 1.469~1.473 重金属(GT-16-2；试样2g) ≤10mg/kg - 碘值(OT-27-2) 145~160 140~160 灼烧残渣(GT-S；试样10g) ≤0.01% ≤0.01% 皂化值(OT-40-2；试样量3g) 194～202 194～202 不皂化物(OT-46；试样10g) ≤2.0% ≤2.0% 水分(GT-32-1) ≤0.5% ≤0.5% d 25 25 - 0.898~0.904 熔点 - -5℃
Alfa Aesar:亚油酸,tech.75% Linoleic acid, tech. 75%(60-33-3)
Acros Organics:亚油酸/“顺-9, 12-十八碳-二烯酸” Linoleic acid, 99%(60-33-3)
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