CAS 599-79-1 MFCD00057363-2-Hydroxy-5-((4-(N-(Pyridin-2-Yl)Sulfamoyl)Phenyl)Diazenyl)Benzoic Acid 2-羟基-5-((4-(N-(吡啶-2-基)氨磺酰基)苯基)偶氮基)苯甲酸 TAO{mole}

2-Hydroxy-5-((4-(N-(Pyridin-2-Yl)Sulfamoyl)Phenyl)Diazenyl)Benzoic Acid 2-羟基-5-((4-(N-(吡啶-2-基)氨磺酰基)苯基)偶氮基)苯甲酸

CAS 599-79-1 MFCD00057363

化学结构图

SMILES: O=C(O)c1cc(N=Nc2ccc(S(=O)(=O)Nc3ccccn3)cc2)ccc1O

化学属性

Mol. Formula	C18H14N4O5S
Mol. Weight	398
Melting Point	246
Solubility	Soluble in DMSO (100 mg/ml), dichloromethane, ethanol (1:2900), methanol (1:1500), aqueous sodium bicarbonate, sodium hydroxide solutions, and 1 M NH4OH (50 mg/ml). Insoluble in water.
Appearance	其外观为棕黄色微细结晶，无臭。微溶于乙醇，不溶于水、氯仿、乙醚、苯。
Stability	对光敏感

别名和识别编码

Chemical Name	2-Hydroxy-5-((4-(N-(Pyridin-2-Yl)Sulfamoyl)Phenyl)Diazenyl)Benzoic Acid
CAS Number	599-79-1
Synonym	######## 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid 5-[对-(2-吡啶胺磺酰基)苯]偶氮水杨酸 Salicylazosulfapyridine 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene 5-((p-(2-pyridylsulfamoyl)phenyl)azo)-salicyli 5-(4-(2-pyridylsulfamoyl)phenylazo)-2-hydroxybenzoicacid 5-[4-(2-P 5-[4-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID 5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic Acid 5-[对-(2-吡啶胺磺酰基)苯]偶氮水杨酸 Asulfidine Azopyrin Azulfadine Azulfidine Azulfidine EN Benzosulfa Colo Pleon Colo-Pleon LABOTEST-BB LT00772281 Pleon Pyralin EN SULFASALAZINE Salazopyrin Salazosulfapyridine Salicylazosulfapyridine Sulfasalazin Heyl Sulfasalazin medac Sulfasalazin-Heyl
MDL Number	MFCD00057363
Beilstein Registry Number	356241
EC Number	209-974-3
Reaxys-RN	356241
PubChem Substance ID	5339
Merck Number	8942
Chemical Name Translation	2-羟基-5-((4-(N-(吡啶-2-基)氨磺酰基)苯基)偶氮基)苯甲酸
Wiswesser Line Notation	T6NJ BSWMR DNUNR DQ CVQ
InChI	InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer

安全信息

GHS Symbol

WGK Germany2

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
P301+P312
P302+P352
P304+P341
P308+P313
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P313
P342+P311
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害

RTECSVO6250000

Signal word Danger Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S29/56 Do not empty into drains, dispose of this material and its container at hazardous or special waste collection point 不要排入下水道，在危险废物或特殊废物收集点处置该物料及其容器；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Hazard Codes 9

Risk Statements

R42/43

Storage condition 储存温度-20°C

UN Number 3077

Packing GroupIII

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 177 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-457,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 141 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-457,1997

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3870 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,420,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 357 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - headache
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   29,543,1991

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 3200 mg/kg/31D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
   Blood - other changes
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
REFERENCE :
   JRSMD9 Journal of the Royal Society of Medicine.  (Oxford Univ. Press,
   Walton St., Oxford OX2 6DP, UK)  V.71-    1978-  Volume(issue)/page/year:
   73,587,1980

{hazard_com

TYPE OF TEST            : TDLo - Lowest

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 140 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - headache
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,917,1984

TYPE OF TEST            : LD50 - Lethal dose, 50 per

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,27,1989

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 222,27,1989

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 5634 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 283,53,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7 gm/kg
SEX/DURATION            : male 35 day(s) pre-mating
TOXIC EFFECTS :

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 43875 mg/kg
SEX/DURATION            : male 13 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-457,1997

TYPE OF TEST            : TDL

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 16800 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 37,539,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 8100 mg/kg
SEX/DURATION            : female 1-40 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   NEJMAG New England Journal of Medicine.  (Massachusetts Medical Soc., 10
   Shattuck St., Boston, MA 02115)  V.198-    1928-  Volume(issue)/page/year:
   318,1128,1988

其他信息

Sigma Aldrich:599-79-1(sigmaaldrich)
MOL 文件:599-79-1.mol
柳氮磺胺吡啶
MSDS 信息:Salicylazosulfapyridine(599-79-1).msds
F:8
柳氮磺吡啶价格(试剂级):更新日期产品编号产品名称包装价格 2011/04/16 S0580 柳氮磺吡啶 Sulfasalazine 25G 987元
Sulfasalazine 是一种磺胺剂，是Mesalazine的衍生物，主要用作抗炎剂。
用途一:肠道磺胺药，与结缔组织有特殊的亲和力，系目前治疗慢性溃疡结膜炎较好的药物
柳氮磺吡啶价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 S0580 柳氮磺吡啶 Sulfasalazine 25G 889元
方法一:2-氨基吡啶与N-乙酰氨基-苯磺酰氯反应，随后水解得到磺酰吡啶胺，即磺胺吡啶，磺胺吡啶重氮化后与水杨酸偶合、酸化即制得柳氮磺胺吡啶。
上游原料:乙酸 --> 2-氨基吡啶 --> 苯磺酰氯 --> N-乙酰苯胺 --> 磺胺吡啶
用途二:肠道磺胺药，与结缔组织有特殊的亲和力，系目前治疗慢性溃疡结膜炎较好的药物。