N-formyl-[U-13C-15N]-Met-Leu-Phe-OH N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸
CAS 59880-97-6 MFCD00036780
化学结构图
SMILES: CC(O)=O.CC(O)=O.CC(O)=O.N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O |&1:13,27,34,42,53,62,66,77|
化学属性
| Mol. Formula | C21H31N3O5S |
|---|---|
| Mol. Weight | 437.56 |
| Appearance | powder |
| Solubility | DMF: 50 mg/mL, clear, colorless |
别名和识别编码
| Chemical Name | N-formyl-[U-13C-15N]-Met-Leu-Phe-OH |
|---|---|
| Synonym | Chemotactic peptide N-Formyl-L-methionyl-L-leucyl-L-phenylalanine fMLF fMLP (misnomer but widely used) N-FORMYL-MET-LEU-PHE N-Formyl-Met-Leu-Phe N-甲酰-L-甲硫氨酰-L-白氨酰-L苯丙氨酸 |
| MDL Number | MFCD00036780 |
| PubChem Substance ID | 24894846 |
| Beilstein Registry Number | 2315783 |
| CAS Number | 59880-97-6 |
| EC Number | 227-781-2 |
| Chemical Name Translation | N-甲酰-甲硫氨酰-亮氨酰-苯丙氨酸 |
| Reaxys-RN | 2315783 |
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分类
- {SNA} Other Peptides, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Cell Biology, Cell Signaling and Neuroscience, F, FM - FZ, Other Peptides, Peptides and Proteins, Peptides for Cell Biology
- {SNA} Chemotactic Peptides, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators, Immunomodulators and Antibiotics, Peptides and Proteins, Peptides for Cell Biology, 细胞信号转导和神经科学, 细胞生物学
- Bioactive Small Molecules, Cell Biology,
相关文献及参考
- 1. Showell, H.J., et al. J. Exp. Med. 143 , 1154, (1976)
- 2. Homma, Y., et al. Biochem. J. 229 , 643, (1985)
- Anton, P., et al., Mucosal subepithelial binding sites for the bacterial chemotactic peptide, formyl-methionyl-leucyl-phenylalanine (FMLP). Gut 42 , 374-379, (1998) 摘要
- Niedel, J., et al., Receptor-mediated uptake and degradation of 125 I-chemotactic peptide by human neutrophils. J. Biol. Chem. 254 , 10700-10706, (1979) 摘要
- Panaro, M.A., and Mitolo, Y., Cellular responses to FMLP challenging: a mini-review. Immunopharmacol. Immunotoxicol. 21 , 397-419, (1999) 摘要
- Hagi, A., Activation of G-protein coupled fMLP or PAF receptor directly triggers glucose transporter type 1 (GLUT1) translocation in Chinese hamster ovary (CHO) cells stably expressing fMLP or PAF receptor. J. Med. Invest. 47 , 19-28, (2000) 摘要
- Murikinati, S., et al., Activation Of Cannabinoid 2 Receptors Protects Against Cerebral Ischemia By Inhibiting Neutrophil Recruitment. FASEB J. 24 , 788-98, (2010) 摘要
- Myers, S.A., et al., CD47 Knockout Mice Exhibit Improved Recovery From Spinal Cord Injury. Neurobiol. Aging 42 , 21-34, (2011) 摘要
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
其他信息
- Sigma Aldrich:5979-11-3(sigmaaldrich)
- MOL 文件:5979-11-3.mol
- color:white
- F:3-10-23
