5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-Yl)Quinoxalin-6-Amine 5-溴-N-(4,5-二氢-1H-咪唑-2-基)喹喔啉-6-胺
CAS 59803-98-4 MFCD00153878
化学结构图
SMILES: [2H]C1([2H])NC(NC2=CC=C3N=CC=NC3=C2Br)=NC1([2H])[2H]
化学属性
| Mol. Formula | C11H10BrN5 |
|---|---|
| Mol. Weight | 292.14 |
| Melting Point | 245.0 to 249.0 deg-C |
别名和识别编码
| Chemical Name | 5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-Yl)Quinoxalin-6-Amine |
|---|---|
| Synonym | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine Brimonidine 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine Brimonidine LK 14304-18 UK 14,304 UK 14304 |
| MDL Number | MFCD00153878 |
| PubChem Substance ID | 253659653 |
| Beilstein Registry Number | 0751629 |
| CAS Number | 59803-98-4 |
| Chemical Name Translation | 5-溴-N-(4,5-二氢-1H-咪唑-2-基)喹喔啉-6-胺 |
| Reaxys-RN | 751629 |
| Merck Number | 1375 |
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分类
- {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, U
- {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission,
- {SNA} Adrenergics,
- {SNA} Adrenergics,
相关文献及参考
- [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.
- [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.
- [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.
- [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.
- [2]. Cambridge, D., UK-14,304, a potent and sele
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P301+P310
- P301+P310+P330
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 160 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #81-02912
