CAS 5976-61-4 MFCD00063335-4-Hydroxyestradiol 4-hydroxyestradiol TAO{mole}

4-Hydroxyestradiol 4-hydroxyestradiol

CAS 5976-61-4 MFCD00063335

化学结构图

SMILES: C[C@]12CC[C@@H]3c4ccc(O)c(O)c4CC[C@H]3[C@@H]1CC[C@@H]2O

化学属性

Mol. Formula	C18 H24 O3
Mol. Weight	288.38
Melting Point	>190°C (dec.)
Boiling Point
Flash Point	-

别名和识别编码

Chemical Name	4-Hydroxy-17β-estradiol
CAS Number	5976-61-4
Synonym	(17?)-Estra-1,3,5(10)-triene-3,4,17-triol 1,3,5(10)-Estratriene-3,4,17β-triol 4-Hydroxy-17-beta-estradiol 4-Hydroxy-17Beta-estradiol 4-Hydroxy-17b-estradiol 4-Hydroxy-17beta-estradiol {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol-17 beta {} {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol-17 alpha {} {} {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol-17 beta {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol-17 alpha {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} 4-hydroxyestradiol {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
MDL Number	-
PubChem Substance ID	5282360
Chemical Name Translation	4-hydroxyestradiol
InChI	InChI=1S/C18H24O3/c1-18-9-8-11-10-4-6-15(19)17(21)13(10)3-2-12(11)14(18)5-7-16(18)20/h4,6,11-12,14,16,19-21H,2-3,5,7-9H2,1H3/t11-,12-,14+,16+,18+/m1/s1
Canonical SMILES	-

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产品应用

A metabolite of Estradiol.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313
P318
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H351 Suspected of causing cancer 怀疑致癌

RTECSKG7676000

Signal word Warning

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes Xn

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 900 mg/kg/90D-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
   JSTBBK Journal of Steroid Biochemistry.  (Pergamon Press Ltd., Headington
   Hill Hall, Oxford OX3 0BW, UK)  V.1-    1969-  Volume(issue)/page/year:
   24,353,1986

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 14 mg/kg/7D (Continuous)
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 15,997,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 ug/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   EXPEAM Experientia.  (Birkhaeuser Verlag, POB 133, CH-4010 Basel,
   Switzerland)  V.1-    1945-  Volume(issue)/page/year: 42,165,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1280 ng/kg
SEX/DURATION            : male 8 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
   Endocrine - androgenic
REFERENCE :
   ANDRDQ Andrologia.  (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000
   Berlin 30, Fed. Rep. Ger.) V.6-    1974-  Volume(issue)/page/year:
   23,339,1991

Storage condition -20 -20°C -20°C, Hygroscopic -20℃