CAS 59-87-0 MFCD00003225-2-((5-Nitrofuran-2-yl)methylene)hydrazine-1-carboxamide 2-(5-硝基呋喃-2-基)亚甲基)肼-1-甲酰胺 TAO{mole}

2-((5-Nitrofuran-2-yl)methylene)hydrazine-1-carboxamide 2-(5-硝基呋喃-2-基)亚甲基)肼-1-甲酰胺

CAS 59-87-0 MFCD00003225

化学结构图

SMILES: NC(=O)NN=Cc1ccc([N+](=O)[O-])o1

化学属性

Mol. Formula	C6H6N4O4
Mol. Weight	198
Melting Point	242-244
TSCA	Yes
Solubility	<0.1 G/100 ML AT 19 ºC
Flash Point	2 °C
Appearance	黄色结晶性粉末。熔点236-240℃（分解）。1份该品可溶于4200份水、590份乙醇，几乎不溶于乙醚、氯仿。饱和溶液的pH为6.0-6.5。无臭，味苦。日光下色渐变深。
Density	1.7
Stability	对光线敏感

别名和识别编码

Chemical Name	2-((5-Nitrofuran-2-yl)methylene)hydrazine-1-carboxamide
CAS Number	59-87-0
Synonym	######## (5-Nitro-2-furfurylideneamino)urea 2((5-Nitro-2-fu 2-((5-nitro- 2-Furancarboxaldehyde, 5-n 5-NITRO-2-FURALDEHYDE SEMICARB 5-NITRO-2-FURFURYLIDENE SEMICARBAZONE 5-Nitrofurfural semicarbazone 5-Nitrofurfurolsemicarbazon Amifur Cocafurin Coxistat Dermofural Furaci Furacilin Furacilinum Furacycline Furan-ofteno Furosem Hemofuran Hydrazinecarboxamide, 2-[(5-nitro-2-furanyl)methylene]- LABOTEST-BB LT00134617 Mammex Monafuracin NCI-C56064 NFS NSC-2100 Nfz mix Nitrofuraldehyde semi Nitrofuran Nitrofurazan Nitrofurazone USAF
MDL Number	MFCD00003225
PubChem Substance ID	87573571
Beilstein Registry Number	86403
EC Number	200-443-1
Reaxys-RN	86403
Merck Number	6600
Chemical Name Translation	2-(5-硝基呋喃-2-基)亚甲基)肼-1-甲酰胺
Wiswesser Line Notation	T5OJ BNW E1UNMVZ
InChI	InChI=1S/C6H6N4O4/c7-6(11)9-8-3-4-1-2-5(14-4)10(12)13/h1-3H,(H3,7,9,11)/b8-3+

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产品应用

该品味硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H302 Harmful if swallowed 吞食有害
H302+H312+H332
H312 Harmful in contact with skin 皮肤接触有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害

Hazard Codes Xn F,Xn Xn,F

RTECSLT7700000

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Signal word Danger Warning

Safety Statements

S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S36 Wear suitable protective clothing 穿戴适当的防护服；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R11 Highly flammable 非常易燃
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R22 Harmful if swallowed 吞咽有害
R36 Irritating to eyes 刺激眼睛
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Storage condition Light Sensitive 2-8°C

Packing GroupIII

Hazard Class6.1(b)

UN Number 3249

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 31 gm/kg/45W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Skin and Appendages - tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 25,419,1966

{hazard_c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10094 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - tumors
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 25,419,1966

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11176 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   27,129,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8652 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-337,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 249 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TRSTAZ Transactions of the Royal Society of Tropical Medicine and Hygiene.
   (Royal Soc. of Tropical Medicine and Hygiene, Manson House, 26 Portland Pl.,
   London W1N 4EY, UK)  V.14-    1920-  Volume(issue)/page/year: 74,43,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 753 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 102,185,1951

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 96 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 10,530,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 590 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   133,299,1947

{hazard_

{haz

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 250 ug/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-337,1988

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 250 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,781,1975

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 500 umol/L/90M (Continuous)
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   40,94,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   BJCSB5 British Journal of Cancer, Supplement.  (Macmillan Press Ltd.,
   Houndmills, Basingstoke, Hants. RG21 2ZS, UK)  No.1-    1973-
   Volume(issue)/page/year: 3,124,1978

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 26,3,1974

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 40 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 175,149,1986

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 700 mg/kg
SEX/DURATION            : male 7 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   APJAAG Acta Pathologica Japonica.  (Japan Publications Trading Co., Ltd.,
   POB 5030, Tokyo International, Tokyo 101-31, Japan)  V.1-    1951-
   Volume(issue)/page/year: 14,261,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1792 mg/kg
SEX/DURATION            : male 28 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 840 mg/kg
SEX/DURATION            : male 14 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   53,585,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 900 mg/kg
SEX/DURATION            : female 9-11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Developm

其他信息

可燃性危险特性:可燃, 火场排出氮氧化物辛辣刺激烟雾
用途一:硝基呋喃类抗菌药，主要用于家禽、家畜及水产鱼类的防病、抗菌
Sigma Aldrich:59-87-0(sigmaaldrich)
急性毒性:口服- 大鼠 LD50 590 毫克/ 公斤; 口服- 小鼠 LD50: 249 毫克/公斤
毒性分级:高毒
TCI Shanghai:5-硝基-2-呋喃醛缩氨基脲 Nitrofurazone,>;98.0%(LC)(E)(59-87-0)
用途三:该品味硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。
F:8
图谱信息:呋喃西林(59-87-0)红外图谱(IR2) 呋喃西林(59-87-0)红外图谱(IR1) 呋喃西林(59-87-0)质谱(MS)
呋喃西林价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 N0200 呋喃西林 Nitrofurazone 25G 95元 2014/06/02 N0200 呋喃西林 Nitrofurazone 250G 570元 2010/05/25 A18593 5-硝基-2-亚糠基半卡巴腙, 98+% 5-Nitro-2-furaldehyde semicarbazone, 98+% 250g 818元
1份该品可溶于4200份水、590份乙醇，几乎不溶于乙醚、氯仿。饱和溶液的ph为6.0-6.5。无臭、味苦。日光下色渐变深。
储运特性:库房低温, 通风, 干燥; 与食品原料分开存放
Alfa Aesar:5-硝基-2-亚糠基半卡巴腙,98+% 5-Nitro-2-furaldehyde semicarbazone, 98+%(59-87-0)
灭火剂:水, 二氧化碳, 干粉, 砂土
MSDS 信息:Furacilin(59-87-0).msds
MOL 文件:59-87-0.mol
方法一:由糠醛经硝化、酯化、水解，制得5-硝基糠醛，再与盐酸氨基缩合而得呋喃西林。
类别:有毒物品
上游原料:乙酐 --> 尿素 --> 水合肼 --> 5-硝基糠醛
用途二:该品为硝基呋喃类抗菌药。这类药物还包括呋喃唑酮、呋喃妥因。呋喃西林口服毒性大，用于外科局部或表面消毒。
敏感性:Light Sensitive