CAS 59-14-3 MFCD00006529-5-Bromo-2'-deoxyuridine 5-溴-2-脱氧尿苷 TAO{mole}

5-Bromo-2'-deoxyuridine 5-溴-2-脱氧尿苷

CAS 59-14-3 MFCD00006529

化学结构图

SMILES: O=c1[nH]c(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1Br

化学属性

Mol. Formula	C9H11BrN2O5
Mol. Weight	307
Density	1.905
Melting Point	191-194
TSCA	Yes
Solubility	Soluble in water (10 mg/mL), NH4OH (0.1 M) at 20 °C, DMF, DMSO, and sodium hydroxide.
Appearance	白色结晶性粉末，无臭、无味。难溶于水和甲醇，几乎不溶于氯仿和苯，易溶于氢氧化钠溶液。mp193-197℃ (分解)。比旋度+23°(C=1，水中)。
Refractive index	22 ° (C=1, H2O)
Stability	对空气敏感

别名和识别编码

Chemical Name	5-Bromo-2'-deoxyuridine
CAS Number	59-14-3
Synonym	(+)-5-Bromo-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 1-(2-脱氧-Β-D-呋喃核糖基)-5-溴尿嘧啶 2'-Deoxy-5-bromouridine 2'-De 5-B 5-BRDU 5-BrdU 5-溴-1-(2-脱氧-β-D-呋喃核糖)尿嘧啶 5-溴脱氧尿苷 BUdR 5-BrdU, 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil, 5-Bromouracil deoxyriboside, BUdR 5-Brom-2'-deoxyuridin 5-Bromouracil-2-deoxyriboside 5-Budr 5-bromo-2'-deoxy-uridine 5-bromouracildeoxyriboside 5-溴-2'-脱氧尿苷 5-溴-2'-脱氧尿苷;5'-溴尿嘧啶核苷;溴脲苷;5-溴-1-(2-脱氧-β 5-溴脱氧尿苷 BDU BRDU LABELING REAGENT Bromodeoxyuridine Broxuridine Uridine, 5-bromo-2'-deoxy- broxuridine (INN) {} {} {Ch {} {} {Chemi {} {} {uni_hamburg} 溴脲嘧啶苷溴脲苷脱氧溴
EC Number	200-415-9
Beilstein Registry Number	30395
MDL Number	MFCD00006529
PubChem Substance ID	6035
Merck Number	14,1452
Chemical Name Translation	5-溴-2-脱氧尿苷
Reaxys-RN	4236087
Wiswesser Line Notation	T6NVMVJ EE A- ET5OTJ B1Q CQ
LabNetwork Molecule ID	LN00189260
InChI	InChI=1S/C9H11BrN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1

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产品应用

胸腺嘧啶类似物，在遗传学研究中用作诱变剂（mutagen），在细胞分裂的S-期选择性地插进DNA。

安全信息

Signal word Danger

GHS Symbol

WGK Germany2

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R46 May cause inheritable genetic damage 可能引起遗传基因损害
R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P308+P313

RTECSYU7350000

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H340 May cause genetic defects 可能导致遗传性缺陷

Hazard Codes T Xn

Storage condition -20℃保存 2-8°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 295,113,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 30,530,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal o

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,721,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532,
   Japan)  V.29-    1970-  Volume(issue)/page/year: 30,530,1971

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   GENTAE Genetics.  (Genetics Business Office, POB 64025, Baltimore, MD 21264)
    V.1-    1916-  Volume(issue)/page/year: 51,545,1965

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Testis
DOSE/DURATION           : 15 mg/L
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 38,159,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 7500 ng/L
REFERENCE :
   JNCSAI Journal of Cell Science.  (Biochemical Soc. Book Depot, POB 32,
   Commerce Way, Colchester, Essex CO2 8HP, UK)  V.

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Ovary
DOSE/DURATION           : 20 mg/L
REFERENCE :
   CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK)  V.1- 1969- 
   Volume(issue)/page/year: 38,159,1983

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Mammal - cattle Lymphocyte
DOSE/DURATION           : 20 mg/L
REFERENCE :
   CARYAB Caryologia.  (Via G. LaPira 4, 50121 Florence, Italy)  V.1-    1948-
   Volume(issue)/page/year: 36,285,1983

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 30 mg/L
REFERENCE :
   MGGEAE Molecular and General Genetics.  (Springer-Verlag, Heidelberger Pl.
   3, D-1000 Berlin 33, Fed. Rep. Ger.)  V.99-    1967-
   Volume(issue)/page/year: 171,135,1979

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Mammal - species unspecified
DOSE/DURATION           : 1 gm/k

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 8-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   REPTED Reproductive Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1987-  Volume(issue)/page/year:
   11,663,1997

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 200 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   TAKHAA Takeda Kenkyusho Ho.  Journal of the Takeda Research Laboratories.
   (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusoh

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 11 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 34,412,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous

其他信息

5-Bromo-2'-deoxyuridine is a thymidine analog. Useful for the study of DNA synthesis where it is incorporated into DNA in place of thymidine. 5-Bromo-2'-deoxyuridine can be used to label DNA. The resulting DNA can be used in conjunction with BrdU Monoclonal Antibody for the immunohistochemical analysis of cell proliferation.
灭火剂:水,干粉,二氧化碳,泡沫,沙土
类别:有毒物质
Alfa Aesar:5-溴-2'-脱氧尿苷,99% 5-Bromo-2'-deoxyuridine, 99%(59-14-3)
F:10-23
Sigma Aldrich:59-14-3(sigmaaldrich)
急性毒性:口服-大鼠 LD50: 8400 毫克/公斤; 口服-小鼠 LD50: 9100 毫克/公斤
毒性分级:低毒
可燃性危险特性:热分解排出有毒氮氧化物和溴化物烟雾
TCI Shanghai:5-溴-2'-脱氧尿苷 5-Bromo-2'-deoxyuridine,>;98.0%(LC)(T)(59-14-3)
用途一:用于脑瘤和头颈部肿瘤的放射增敏剂，从而提高放疗效果。与抗代谢剂合用亦能提高疗效。
Acros Organics:5-溴-2'-脱氧尿苷 5-Bromo-2'-deoxyuridine, 99+%(59-14-3)
比旋光度:31 ° (c=1, 0.1N NaOH)
图谱信息:溴脲苷(59-14-3)质谱(MS) 溴脲苷(59-14-3)红外图谱(IR2) 溴脲苷(59-14-3)红外图谱(IR1) 溴脲苷(59-14-3)核磁图( 13 CNMR) 溴脲苷(59-14-3)核磁图( 1 HNMR)
MOL 文件:59-14-3.mol
储运特性:库房通风低温干燥
MSDS 信息:5-Bromo-2'-deoxyuridine(59-14-3).msds
用途二:胸腺嘧啶类似物，在遗传学研究中用作诱变剂（mutagen），在细胞分裂的S-期选择性地插进DNA。
溴脲苷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 k1688001 5-溴－2’－脱氧尿苷（+4℃） 250mg 386元 2011/08/23 SB500201 5-溴-2’-脱氧尿苷（-20℃） 100mg 502元 2011/04/16 B1575 5-溴-2'-脱氧尿苷 5-Bromo-2'-deoxyuridine 1G 920元