Prostinfenem 卡前列素氨基丁三醇
CAS 58551-69-2 MFCD01694769
化学结构图
SMILES: C[C@](O)(CCCCC)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(O)=O)[C@@H](O)C[C@H]1O.NC(CO)(CO)CO
化学属性
| Mol. Formula | C21H36O5.C4H11NO3 |
|---|---|
| Mol. Weight | 489.73 |
别名和识别编码
| Chemical Name | Prostinfenem |
|---|---|
| Wiswesser Line Notation | L5TJ AQ B2U4VQ C1U1XQ5&1 DQ &Q1XZ1Q1Q |
| Synonym | 15(S)15-Methyl pgf2-alpha tromethamine salt 15(S)15-Methyl prostaglandin F2-alpha tromethamine Carboprost tromethamine |
| CAS Number | 58551-69-2 |
| Chemical Name Translation | 卡前列素氨基丁三醇 |
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相关文献及参考
- [2]. Bai J, et al. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. Epub 2013 Nov 1.
- [1]. Ling Z, et al. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262.
- [1]. Ling Z, et al. Effect of carboprost tromethamine in prevention of postpartum hemorrhage in cesarean section. Pak J Pharm Sci. 2018 Sep;31(5(Special)):2257-2262.
- [2]. Bai J, et al. A comparison of oxytocin and carboprost tromethamine in the prevention of postpartum hemorrhage in high-risk patients undergoing cesarean delivery. Exp Ther Med. 2014 Jan;7(1):46-50. Epub 2013 Nov 1.
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 131 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 25100 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY) V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978
TYPE OF TEST : TDLo - Lowest p
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 6 mg/kg
SEX/DURATION : male 3 day(s) pre-mating
female 3 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 87 ug/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - stillbirth
Reproductive - Effects on Newborn - live birth index (measured after birth)
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4
per # born alive)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE : 87 ug/kg
SEX/DURATION : female 15-22 day(s) after conception
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Maternal Effects - parturition
Reproductive - Fertility - abortion
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
APTRDI Advances in Prostaglandin and Thromboxane Research. (New York, NY)
V.1-8, 1976-80. Volume(issue)/page/year: 4,157,1978