CAS 58-63-9 MFCD00066770-Inosine, 99% 肌苷 TAO{mole}

Inosine, 99% 肌苷

CAS 58-63-9 MFCD00066770

化学结构图

SMILES: O=c1[nH]cnc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

化学属性

Mol. Formula	C10H12N4O5
Mol. Weight	268.23
Density	2.08
Melting Point	222-226°C
TSCA	Yes
Solubility	2.1 G/100 ML (20 ºC)
Appearance	本品为白色结晶性粉末；无臭；味微苦。在水中略溶，在氯仿、乙醇中不溶，在稀盐酸或氢氧化钠等碱溶液中易溶。本品的饱和水溶液约含肌苷1.5%。 mp218℃(分解)。
Refractive index	-52 ° (C=1, H2O)
Boiling Point	226 °C at 760 mmHg

别名和识别编码

Chemical Name	Inosine, 99%
CAS Number	58-63-9
Synonym	(-)-Inosine Hypoxanthine 9-β-D-ribofuranoside 1,9-Dihydro-9-?-D-ribofuranosyl-6H-purin-6-one 1,9-Dihydro-9β-D-ribofuranosyl-6H-purin-6 6-HYDROXYPURINE RIBOSIDE 6H-Purin-6-one, 1,9-dihydro-9β-D-ribofuranosyl- 9-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1,9-DIHYDRO-PURIN-6-ONE 9-B-D-RIBOFURANOSYLHYPOXANTHINE 9-BETA-D-RI 9-BETA-RIBOFURANOSY 9-D-核糖次黄嘌呤 9-[3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-3H-PURIN-6-ONE 9-β-D-Ribofuranosylhypo 9-β-D-呋喃核糖基次黄嘌呤 9-次黃嘌呤-Β-D-核[呋喃糖]苷 Atorel HXR HYPOXANTHINE 9-D-RIBOFURANOSIDE HYPOXANTHINE RIBONUCLEOSIDE HYPOXANTHINE RIBOSIDE HYPOXANTHINE-9-BETA-D-RIBOFURANOSIDE Hyp Hypoxanth Hypoxanthin-9-D-ribofuranosid Hypoxanthine 9-?-D-ribofuranoside Hypoxanthine D-riboside Hypoxanthine Ribonucleoside Hypoxanthine nucleoside Hypoxanthine ribonucleoside Hypoxanthine ribonucleoside; (-)-Ino Hypoxanthine riboside Hypoxanthine, 9-beta-D-ribofuranosyl- Hypoxanthine, 9β-D-ribofuranosyl- Hypoxanthine-9-beta-D-ribofuranoside Hypoxanthine-9-β-D-ribofuranoside Hypoxanthosine INO INO 495 INOSINE Inosine Oxiamin Panholic-L Pantholic-L Selfer Trophicardyl beta-D-Ribo inosine (INN) {} {C {} {Ch {} {u {} {un {} {uni_hambur β-D-Ri β-Inosine 次黄嘌呤核苷（肌苷）次黄苷次黄苷/肌苷肌甙肌苷肌苷, 98+% {Chemicalbo
MDL Number	MFCD00066770
EC Number	200-390-4
Beilstein Registry Number	624889
Merck Number	4975
PubChem Substance ID	87571444
Reaxys-RN	624896
Chemical Name Translation	肌苷
Wiswesser Line Notation	T56 BN DN FN HNJ IQ D- BT5OTJ CQ DQ E1Q
LabNetwork Molecule ID	LN00193903
InChI	InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1
Canonical SMILES	O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N2C=NC3=C2N=CNC3=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

肌苷是神经生产因子（NGF)潜在的刺激因子。

安全信息

Signal word Warning

GHS Symbol

WGK Germany2

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

RTECSNM7460000

Storage condition 2-8°C {LY} 2-8°C Store at RT. {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 20,160,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,77,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >20 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,77,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,156,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 60 mmol/L
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 48,686,1962

其他信息

用途五:肌苷是神经生产因子（NGF)潜在的刺激因子。
Acros Organic
用途一:生化研究。医药用于促进白细胞增长
用途三:参与体内能量代谢和蛋白质的合成。可用于治疗由于各种原因引起的白细胞减少、血小板减少等。可引起轻度腹泻，不能与乳清酸、氯霉素、潘生丁及硫喷妥钠注射液配伍。
方法一:方法一、肌苷酸脱磷酸法肌苷酸二钠的制备棒状杆菌269发酵，发酵液去菌体，吸附，洗脱，浓缩，加乙醇，pH7-7.5条件下结晶可得肌苷酸二钠。棒状杆菌269[发酵]→发酵液[去菌体，吸附，洗脱，浓缩]→浓缩液[乙醇]→[pH7-7.5]肌苷酸二钠肌苷粗品的制备在乙酸缓冲液中，调pH5.4-5.6，加压137-147kPa，脱磷酸5h，可得肌苷粗品。肌苷酸二钠[乙酸，加压]→肌苷精制蒸馏水溶解，pH=6，重结晶，可得精品。方法二、一步发酵法菌株选育变异芽孢杆菌7171-9-1移接到斜面培养基上，30-32℃培养48h。斜面培养基成分为葡萄糖1%，蛋白胨0.4%，酵母浸膏0.7%，牛肉浸膏1.4%，琼脂2%，在pH7、120℃灭菌20min。变异芽孢杆菌7171-9-1[斜面培养]→[30-32℃, 48h]菌种斜面种子培养一级种子：培养基成分为葡萄糖2%，蛋白胨1%，酵母浸膏1%，玉米浆0.5%，尿素0.5%，氯化钠0.25%。灭菌前pH 7，用1L三角瓶装150ml培养基，115℃灭菌15min。每个三角瓶中接入白金耳环菌苔，在往复式摇床上，32℃±1℃培养18h。二级种子：培养基同一级种子，放大50L发酵罐，定容体积25L，接种量 3%，32℃±1℃培养12-15h，搅拌速度320r/min，通风量1：0.25V/(V·min)，生长菌指标 A(650nm)=0.78，pH=6.4-6.6。菌种斜面[摇床振荡]→[pH7, 32℃±1℃, 18h]一级种子培养液[50L发酵罐]→[pH6.4-6.6, 32℃±1℃, 12-15h]二级种子培养液发酵 50L不锈钢标准发酵罐，定容体积35L。培养基成分为淀粉水解糖10%，干酵母水解液1.5%，豆饼水解液0.5%，尿素0.4%，硫酸镁0.1%，氯化钾0.2%，磷酸氢二钠0.5%，硫酸铵1.5%，有机硅油0.05%。pH=7，接种量0.9%，32℃±1℃培养93h，搅拌速度320r/min，通风量1：0.5V/(V·min)。500L发酵罐，定容体积350L。培养基成分为淀粉水解糖10%，干酵母水解液1.5%，豆饼水解液0.5%，硫酸铵1.5%，硫酸镁0.1%，氯化钾0.2%，磷酸氢二钠0.5%，碳酸钙1%，有机硅油小于0.3%。pH=7，接种量7%，32℃±1℃培养75h，搅拌速度230r/min，通风量1：0.25V/(
用途二:用作辅酶类药物
TC
比旋光度:-49.2 ° (c=1,H2O 18 °C)
用途四:本品几乎无毒性和副作用，能直接透过细胞膜进入人体细胞，使处于人低能、缺氧状态下的细胞能继续顺利地进行代谢，并能活化丙酮酸氧化酶类，参与人体蛋白质的合成。主要用于各种类型的肝疾病、心疾患、白血球减少症、血小板减小、中心性视网膜炎以及预防和解除锑剂引起的副作用。
下游产品:DL-色氨酸 --> 利巴韦林 --> 5'-核糖核苷酸钙 --> 地达诺辛 --> 四乙酰核糖
Sigma Aldrich:58-63-9(sigmaaldrich)
{Chemica
方法二:肌苷可通过直接发酵法生产，也可通过半合成法生产。半合成法采用发酵制得的甩苷酸二钠为原料，经脱膦而得肌苷。
图谱信息:肌苷(58-63-9)红外图谱(IR2) 肌苷(58-63-9)核磁图( 1 HNMR) 肌苷(58-63-9)红外图谱(IR1) 肌苷(58-63-9)质谱(MS) 肌苷(58-63-9)核磁图( 13 CNMR)
肌苷价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 65009733 肌苷;次黄嘌呤核苷;9-β-D-呋喃核糖基次黄嘌呤 10g 37.1元 2011/04/16 I0037 肌苷 Inosine 500G 5390元 2011/04/16 I0037 肌苷 Inosine 25G 580元