CAS 58-56-0 MFCD00012807-[4,5-bis(hydroxymethyl)-2-methylpyridin-3-yl]methanol hydrochloride 5-羟基-6-甲基-3,4-二羟甲基吡啶盐酸盐 TAO{mole}

[4,5-bis(hydroxymethyl)-2-methylpyridin-3-yl]methanol hydrochloride 5-羟基-6-甲基-3,4-二羟甲基吡啶盐酸盐

CAS 58-56-0 MFCD00012807

化学结构图

SMILES: Cc1ncc(CO)c(CO)c1O.Cl

化学属性

Mol. Formula	C8H11NO3.HCl
Mol. Weight	206
Melting Point	214-215
TSCA	Yes
Solubility	0.1 G/ML (20 ºC)
Stability	对光线敏感

别名和识别编码

Chemical Name	[4,5-bis(hydroxymethyl)-2-methylpyridin-3-yl]methanol hydrochloride
MDL Number	MFCD00012807
CAS Number	58-56-0
Synonym	Vitamin B6 hydrochloride 5-Hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride Pyridoxinum hydrochloricum Adermin Hydrochloride 3-Hydroxy-4,5-dimethylol-alpha-picoline hydrochloride 吡哆辛盐酸盐, 99% PN HCl 吡哆醇盐酸盐抗皮炎素盐酸盐维生素 B6 盐酸盐维生素B6 Hexavibex PN HCl Pyridoxine HCl 吡哆醇盐酸盐抗皮炎素盐酸盐维生素 B6 盐酸盐 2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine hydrochloride Hexabetalin Becilan 3,4-Pyridinedimethanol, 5-hydroxy-6-methyl-, hydrochloride
PubChem Substance ID	6019
Beilstein Registry Number	3632435
EC Number	200-386-2
Merck Number	7982
Reaxys-RN	3632435
Chemical Name Translation	5-羟基-6-甲基-3,4-二羟甲基吡啶盐酸盐
Wiswesser Line Notation	T6NJ B1 CQ D1Q E1Q &GH
LabNetwork Molecule ID	LN00223476
InChI	InChI=1S/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H

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产品应用

生化研究。

安全信息

WGK Germany2

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

RTECSUV1350000

Storage condition Light Sensitive 密封阴凉干燥保存。储存温度2-8℃

Hazard Codes Xi

Safety Statements

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险

Signal word Danger

Hazard statements

H318 Causes serious eye damage 严重伤害眼睛
H303 May be harmfully swallowed 吞食可能有害

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - cat
DOSE/DURATION           : 560 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 11,922,1961

TYPE OF TEST

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 2 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 124,175,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 5 mg/plate
REFERENCE :
   TRENAF Kenkyu Nenpo--Tokyo-toritsu Eisei Kenkyusho.  Annual Report of Tokyo
   Metropolitan Research Laboratory of Public Health.  (Tokyo-toritsu Eisei
   Kenkyusho, 24-1, 3-chome, Hyakunin-cho, Shin-juku-ku, Tokyo 160, Japan) V.1-
      1949/50-  Volume(issue)/page/year: 37,447,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   66,198,1992

TYPE OF TEST            : TDL

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 7500 mg/kg
SEX/DURATION            : male 6 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland,
   accessory glands
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   66,198,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 gm/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TOLED5 Toxicology Letters.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1977-  Volume(issue)/page/year: 39,159,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 15 gm/kg
SEX/DURATION            : male 2 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - testes, epi

其他信息

无气味。味微咸苦。遇光渐变质。在空气中稳定。1g溶于约4.5ml水、90ml乙醇，微溶于丙酮，不溶于乙醚和氯仿。10%水溶液pH3.2。酸性水溶液稳定，即便在加热至120℃(分解并升华)。最大吸收波长(0.1mol/L盐酸)290nm(ε840)、(磷酸盐缓冲，pH7)253、325nm(ε3700、7100)。低毒，半数致死量(大鼠，经口)4000mg/kg。