5-Hexynoic acid, 4-amino-
CAS 57659-38-8 MFCD00468056
化学结构图
SMILES: C#CC(N)CCC(O)=O
化学属性
| Mol. Formula | C6H9NO2 |
|---|---|
| Mol. Weight | 127.16 |
别名和识别编码
| Chemical Name | 5-Hexynoic acid, 4-amino- |
|---|---|
| Synonym | RMI 71645 4-Amino-5-hexynoic acid gamma-Acetylenic gaba |
| MDL Number | MFCD00468056 |
| PubChem Substance ID | 24278145 |
| CAS Number | 57659-38-8 |
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分类
- {SNA} A-AM, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, GABA-Transaminase, Neuroscience, Neurotransmission, Neurotransmitter Metabolism
相关文献及参考
- Schousboe, et al., Stereoselective uptake of GABA-transaminase inhibitors γ-vinyl GABA and γ-acetylenic GABA into neurons and astrocytes. Neurochem. Res. 11 , 1497, (1986) 摘要
- Loscher, γ-Acetylenic GABA antagonizes the decrease in synaptosomal GABA concentrations but not the seizures induced by 3-mercaptoproprionic acid in rats. Biochem. Pharmacol. 15 , 3176-3180, (1986)
- Loscher, et al., Differential effects of vigabatrin, γ-acetylenic GABA, aminooxycetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. Naunyn Schmiedebergs Arch. Pharmacol. 349 , 270-278, (1994) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 310 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Skin and Appendages - hair REFERENCE : NEPHBW Neuropharmacology. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.9- 1970- Volume(issue)/page/year: 21,803,1982
