Methyl (E)-3-(3-(N-((4'-(Dimethylamino)-[1,1'-Biphenyl]-4-Yl)Methyl)Cyclohexanecarboxamido)Phenyl)Acrylate (E)-3-(3-(N-((4’-(二甲基氨基)-[1,1’-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯
CAS 574013-66-4 MFCD09971007
化学结构图
SMILES: CN(C)C1C=CC(=CC=1)C1=CC=C(CN(C2=CC(/C=C/C(=O)OC)=CC=C2)C(=O)C2CCCCC2)C=C1
化学属性
| Mol. Formula | C32H36N2O3 |
|---|---|
| Mol. Weight | 496.647 |
别名和识别编码
| Chemical Name | Methyl (E)-3-(3-(N-((4'-(Dimethylamino)-[1,1'-Biphenyl]-4-Yl)Methyl)Cyclohexanecarboxamido)Phenyl)Acrylate |
|---|---|
| Chemical Name Translation | (E)-3-(3-(N-((4’-(二甲基氨基)-[1,1’-联苯]-4-基)甲基)环己烷甲酰胺基)苯基)丙烯酸甲酯 |
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相关文献及参考
- [2]. Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92.
- [3]. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nat Med. 2015 Feb;21(2):159-65.
- [1]. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7.
- [1]. Lam IP, et al. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP). Am J Physiol Gastrointest Liver Physiol. 2009 Jul;297(1):G90-7.
- [2]. Michael Downes, et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol Cell. 2003 Apr;11(4):1079-92.
- [3]. Fang S, et al. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
