CAS 57-97-6 MFCD00003600-7,12-Dimethylbenz[a]anthracene 7,12-二甲基苯蒽 TAO{mole}

7,12-Dimethylbenz[a]anthracene 7,12-二甲基苯蒽

CAS 57-97-6 MFCD00003600

化学结构图

SMILES: Cc1c2ccccc2c(C)c2c1ccc1ccccc12

化学属性

Mol. Formula	C20H16
Mol. Weight	256.34
Melting Point	122-123 °C
TSCA	Yes
Flash Point	54.44°C
Boiling Point	183-184 °C at 765 mmHg
Refractive index	n20/D 1.501(lit.)
Density	0.9

别名和识别编码

Chemical Name	7,12-Dimethylbenz[a]anthracene, 98.5%, reference material
Synonym	DMBA {LY} DMBA {} {LY} DMBA {} {} {LY} DMBA {} {} {} {LY} DMBA {} {} {} {} {LY} DMBA {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} DMBA {} {} {} {} {} {} {} {} {} {} {} {} {}
CAS Number	57-97-6
PubChem Substance ID	6001
EC Number	200-359-5
Beilstein Registry Number	5(3)2413
MDL Number	MFCD00003600
Reaxys-RN	1912135
Merck Number	3235
Chemical Name Translation	7,12-二甲基苯蒽
Wiswesser Line Notation	L D6 B666J C1 J1
LabNetwork Molecule ID	LN00194807
InChI	InChI=1S/C20H16/c1-13-16-8-5-6-9-17(16)14(2)20-18(13)12-11-15-7-3-4-10-19(15)20/h3-12H,1-2H3
Canonical SMILES	CC(C1=CC=CC=C21)=C3C=CC4=CC=CC=C4C3=C2C

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

DMBA被p450酶氧化产生的代谢物能和DNA共价形成加合物，形成脱嘌呤碱基位点。常用于在动物身上诱导皮肤和乳房瘤，也能诱发白血病和其它瘤。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes 9

Hazard statements

H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H331 Toxic if inhaled 吸入中毒
H350 May cause cancer 可能致癌
H370 Causes damage to organs 导致器官损伤

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSCW3850000

Precautionary statements

P203
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P317
P318
P330 Rinse mouth. 漱口
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R45 May cause cancer 可能致癌
R22 Harmful if swallowed 吞咽有害

Packing GroupIII

Hazard Class6.1(b)

Storage condition 2-8°C {LY} 2-8°C Store at room temperature {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°

UN Number 3077

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,3968,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg
                          female 18-20 day(s) after conception
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Reproductive - Tumorigenic effects - ovarian tumors
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   VOONAW Voprosy Onkologii.  Problems of Oncology.  For English translation,
   see PONCAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-10,
   1928-37; V.1-    1955-  Volume(issue)/page/year: 20(8),65,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 1600 mg/kg/65W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JNC

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1600 ug/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   PEXTAR Progress in Experimental Tumor Research.  (S. Karger AG, Postfach
   CH-4009 Basel, Switzerland) V.1-    1960-  Volume(issue)/page/year:
   26,128,1983

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences.
   (Paris, France)  V.1-261, 1835-1965.  For publisher information, see CRASEV.
    Volume(issue)/page/year: 252,1236,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intratracheal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PWPSA8 Proceedings of the Western Pharmacology Society.  (Univ. of
   California Dept. of Pharmacology, Los Angeles, CA 90024)  V.1-    1958-
   Volume(issue)/page/year: 24,177,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 54 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   147,1153,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 340 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   147,1153,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOS

TYPE OF TEST            : Unscheduled DNA synthesis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
   Press, 428 E. Preston St., Baltimore, MD 21202)  V.1-    1954-
   Volume(issue)/page/year: 25,107,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 6(Suppl
   2),1,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 100 ug/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 2,417,1981

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 200 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 53,152,1978

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 271,201,1992

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Subcutaneous
TEST SYSTEM             : Rodent - hamster
DOSE/DURATION           : 32 umol/kg
REFERENCE :
   HEREAY Hereditas (Lund, Sweden).  (Gjoerloffsgatan 121, S

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IARCCD IARC Scientific Publications.  (Geneva, Switzerland)  No.1-26,
   1971-78.  For publisher information, see IAPUDO.  Volume(issue)/page/year:
   4,112,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6060 ug/kg
SEX/DURATION            : female 8-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnorma

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 25 mg/kg
SEX/DURATION            : male 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   KDIKAX Kobe Daigaku Igakubu Kiyo.  Journal of the Medical Faculty of Kobe
   University.  (Kobe Daigaku Igakubu, 7-chome, Kusumoto-cho, Chuo-ku, Kobe
   650, Japan)  V.30-    1968-  Volume(issue)/page/year: 41,141,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 672 mg/kg
SEX/DURATION            : female 15 day(s) pre-mating  - 5 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
   Reproductive - Effects on Newborn - germ cell effects (in offspring)
REFERENCE :
   DOESD6 DOE Symposium Series.  (NTIS, 5285 Port Royal Rd., Springfield, VA
   22161)  No.45-    1978-  Volume(issue)/page/year: 54,410,1981

其他信息

用途一:DMBA被p450酶氧化产生的代谢物能和DNA共价形成加合物，形成脱嘌呤碱基位点。常用于在动物身上诱导皮肤和乳房瘤，也能诱发白血病和其它瘤。
Sigma Aldrich:57-97-6(sigmaaldrich)
图谱信息:9,10-二甲基-1,2-苯并蒽(57-97-6)红外图谱(IR1) 9,10-二甲基-1,2-苯并蒽(57-97-6)质谱(MS) 9,10-二甲基-1,2-苯并蒽(57-97-6)核磁图( 13 CNMR) 9,10-二甲基-1,2-苯并蒽(57-97-6)红外图谱(IR2) 9,10-二甲基-1,2-苯并蒽(57-97-6)核磁图( 1 HNMR)
Acros Organics:7,12-二甲基苯并(a)蒽 7,12-Dimethylbenz[a]anthracene, 99%(57-97-6)
F:10-13-23
TCI Shanghai:7,12-二甲基苯并[a]蒽 7,12-Dimethylbenz[a]anthracene,>;98.0%(GC)(57-97-6)
MOL 文件:57-97-6.mol
9,10-二甲基-1,2-苯并蒽价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D0677 7,12-二甲基苯并[a]蒽 7,12-Dimethylbenz[a]anthracene 1G 1200元 2014/06/02 D0677 7,12-二甲基苯并[a]蒽 7,12-Dimethylbenz[a]anthracene 5G 4760元 2010/06/21 408180010 9,10-二甲基-1,2-苯并蒽 7,12-Dimethylbenz[a]anthracene 99% 1 GR 1609元
下游产品:氟氯菊酯 --> (2-溴苯基)二甲胺
Alfa Aesar:7,12-Dimethylbenz[a]anthracene, 99%(57-97-6)