CAS 57-56-7 MFCD00042824-Hydrazinecarboxamide 氨基甲酰肼 TAO{mole}

Hydrazinecarboxamide 氨基甲酰肼

CAS 57-56-7 MFCD00042824

化学结构图

SMILES: NNC(N)=O

化学属性

Mol. Formula	CH5N3O
Mol. Weight	75.07
Appearance	白色片状结晶。熔点96℃。易溶于水，不溶于乙醇和乙醚。易潮解。
Melting Point	96 °C
Boiling Point	133.71 °C at 760 mmHg

别名和识别编码

Chemical Name	Hydrazinecarboxamide
Synonym	Hydrazinecarboxamide {LY} Hydrazinecarboxamide {} {LY} Hydrazinecarboxamide {} {} {LY} Hydrazinecarboxamide {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Hydrazinecarboxamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}
MDL Number	MFCD00042824
CAS Number	57-56-7
PubChem Substance ID	5196
EC Number	200-339-6
Chemical Name Translation	氨基甲酰肼
Wiswesser Line Notation	ZVMZ
Beilstein Registry Number	0506319
LabNetwork Molecule ID	LN01075682
InChI	InChI=1S/CH5N3O/c2-1(5)4-3/h3H2,(H3,2,4,5)
Canonical SMILES	NNC(N)=O

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安全信息

WGK Germany3

Hazard Codes Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 gm/kg/30W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   51,83,1960

RTECSVT2975000

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APEPA2 Naunyn-Schmiedebergs Archiv fuer Pharmakologie und Experimentelle
   Pathologie.  (Berlin, Ger.) V.254-263, 1966-69.  For publisher information,
   see NSAPCC.  Volume(issue)/page/year: 257,296,1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 176 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 126 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 122,110,1958

{hazard_co

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 125 ug/well
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 133,161,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 67 umol/plate
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,1469,1981

Hazard statements

H301 Toxic if swallowed 吞食有毒
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P316
P302+P352
P304+P340
P305+P351+P338
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Storage condition

其他信息

Sigma Aldrich:57-56-7(sigmaaldrich)
MOL 文件:57-56-7.mol
方法一:1.尿素-水合肼合成法由尿素与水合肼缩合而得。将40%的水合肼和尿素按摩尔比1.515：1投入反应锅中混合，搅拌加热，于95-103℃回流8h。降温过滤，得氨基脲水溶液，可直接用于有机合成。有时候也将氨基脲水溶液加盐酸，放置后过滤，得到盐酸氨基脲[CAS：563-41-7]。盐酸氨基脲的熔点为175℃。2.硫酸肼-氰酸钠法硫酸肼与氰酸钠反应制得。
下游产品:氢化可的松 --> 对甲基苯乙酮 --> 盐酸氨基脲 --> (Z)-9-环十七烯-1-酮 --> 2,6-二羟基嘌呤 --> 呋喃妥因 --> 薄荷酮 --> 酮麝香 --> 4-苯基脲唑 --> 丙酮缩氨脲
用途一:有机合成原料，也是医药、农药的中间体和测定醛、酮的试剂。用于生产呋喃西啉、硝基呋喃妥因等药物。
上游原料:尿素 --> 硫酸肼 --> 氰酸钠 --> 盐酸氨基脲