CAS 57-53-4 MFCD00063428-Meprobamate Meprobamate TAO{mole}

Meprobamate Meprobamate

CAS 57-53-4 MFCD00063428

化学结构图

SMILES: CCCC(C)(COC(N)=O)COC(N)=O

化学属性

Mol. Formula	C9H18N2O4
Mol. Weight	218.29
Flash Point	11 °C
Appearance	白色流动性粉末，有硫化物特殊气味。可溶于水。

别名和识别编码

Chemical Name	CIV (200 mg)
CAS Number	57-53-4
Synonym	######## 2,2-Di(carbamoyloxymethyl)pentane 2-METHYL-2-PROPYL-1, 2-METHYL-2-PROPYLPROPANE-1,3-DIOL DICARBAMATE 2-Methyl-2-n-propyl-1,3-propanediol dicarbamate 2-Methyl-2-propylpropane-1,3-diol dicarbamate; 2-Methyl-2-propyltrimethylene carbamate 2-methyl-2-n-propyl-1,3-propanedioldicarbamate 2-methyl-2-propyltrimethylenecarbamate 2-metil-2-n-propil-1,3-propanedioldicarbamato 3pbamate Amepromat Amosene Anathylmon Anatimon Andaksin Andaxin Ansiatan Arcoba Artolon Atraxin Ayermate Bamo 400 Biobamat Brobamate Calmiren Canquil-400 Cirpon Cyrpon Dapaz Dic
MDL Number	MFCD00063428
EC Number	200-337-5
PubChem Substance ID	4064
Chemical Name Translation	Meprobamate
Wiswesser Line Notation	ZVO1X3&1&1OVZ
Beilstein Registry Number	1788882
InChI	InChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)

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产品应用

An anxiolytic.

安全信息

GHS Symbol

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P312
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H302 Harmful if swallowed 吞食有害

WGK Germany3

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

RTECSTZ0175000

Hazard Codes Xn Xn,T,F

Risk Statements

R22 Harmful if swallowed 吞咽有害
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险

Storage condition 2-8°C

UN Number UN 1230 3/PG 2

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S7 Keep container tightly closed 保存在严格密闭容器中；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 760 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
REFERENCE :
   JAMAAP JAMA, Journal of the American Medical Association.  (AMA, 535 N.
   Dearborn St., Chicago, IL 60610)  V.1-    1883-  Volume(issue)/page/year:
   207,361,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 384 mg/kg
TOXIC EFFECTS :
   Vascular - BP lowering not characterized in autonomic section
   Vascular - regional or general arteriolar constriction
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   NOMDA6 Northwest Medicine.  (Seattle, WA)  V.1-73, 1903-73.  Discontinued.
   Volume(issue)/page/year: 56,321,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 520 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 26,109,1974

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 280 mg/kg
TOXIC EFFECTS :
   Behavioral - coma
   Vascular - BP lowering not characterized in autonomic section
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   OSMJAT Ohio State Medical Journal.  (Ohio State Medical Assoc., 600 S. High
   St., Suite 500, Columbus, OH 43215)  V.1-    1905- Volume(issue)/page/year:
   52,1304,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 26667 ug/kg
REFERENCE :
   PISCAD Proceedings of the Indian Science Congress.  (Indian Science Congress
   Assoc., 14, Dr. Biresh Guha St., Calcutta, 700017, India)  1st- 1914- 
   Volume(issue)/page/year: 59(Pt 3),547,1972

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 750 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   KAIZAN Kaibogaku Zasshi.  Journal of Anatomy.  (Nippon Kaibo Gakkai, c/o
   Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan)  V.1- 1928-
    Volume(issue)/page/year: 38,258,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5500 mg/kg
SEX/DURATION

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 500 mg/kg
SEX/DURATION            : female 10 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   KAIZAN Kaibogaku Zasshi.  Journal of Anatomy.  (Nippon Kaibo Gakkai, c/o
   Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan)  V.1- 1928-
    Volume(issue)/page/year: 38,258,1963

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6400 mg/kg
SEX/DURATION            : female 1-22 day(s) after conception
                          lactating female 28 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 202,832,1964

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED

其他信息

方法二:2-甲基戊醛与甲醛进行醛醇缩合反应得到2-甲基-2-丙基丙二醇，然后与光气及氨反应，或与氰酸钠及盐酸反应制得甲丙氨酯。
上游原料:丙二醇 --> 氰酸钠 --> DL-蛋氨酸 --> 3-羟基丁醛 --> 2-甲基戊醛
MOL 文件:57-53-4.mol
Sigma Aldrich:57-53-4(sigmaaldrich)
用途一:本品是饲料营养强化剂，适合于反刍动物，具有在瘤胃中降解的保护作用，用于奶牛饲料中可提高牛奶的产量和牛奶的蛋白质含量，延长产乳期。
MSDS 信息:2-Methyl-2-propylpropane-1,3-diol dicarbamate(57-53-4).msds
方法一:由DL-蛋氨酸为原料生产而得。
用途二:弱安定药。用于治疗神经官能症的焦滤紧张失眠。