CAS 57-44-3 MFCD00036212-Barbital 巴比妥 TAO{mole}

Barbital 巴比妥

CAS 57-44-3 MFCD00036212

化学结构图

SMILES: CCC1(CC)C(=O)NC(=O)NC1=O

化学属性

Mol. Formula	C8H12N2O3
Mol. Weight	184.22
Melting Point	188-192 ºC

别名和识别编码

Chemical Name	Barbital巴比妥
CAS Number	57-44-3
Synonym	######## 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5,5-diethyl- 5,5'-Diethylbarbituric acid 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidinetrione 5,5-Diethyl-2,4,6(1H,3H,5H)-pyrimidintrion 5,5-Diethylbarbituric acid 5,5-Diethylbarbitursäure 5,5-Diethylhexahydropyrimidine-2,4,6-trione 5,5-Diäthylbarbitursäure 5,5-diethyl-pyrimidine-2,4,6-trione 5,5-二乙基-2,4,6(1H,3H,5H)-嘧啶三酮 5,5-二乙基巴比妥酸佛罗拿巴比通 Barbital Barbital (form 2) Barbital (form 3) Barbitone Barbituric acid, 5,5-diethyl- DEBA Deba Diemal Diethyl-barbituric acid Diethylbarbitone Diethylmalonylurea Dormileno Dormonal Ethylbarbital Hypnogene Kyselina 5,5-diethy
MDL Number	MFCD00036212
PubChem Substance ID	2294
Beilstein Registry Number	0163999
EC Number	200-331-2
Wiswesser Line Notation	T6VMVMV FHJ F2 F2
Chemical Name Translation	巴比妥
InChI	InChI=1S/C8H12N2O3/c1-3-8(4-2)5(11)9-7(13)10-6(8)12/h3-4H2,1-2H3,(H2,9,10,11,12,13)

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产品应用

Prototype of the barbiturate hypnotics.

安全信息

RTECSCQ3500000

WGK Germany3

GHS Symbol

Hazard statements

H302 Harmful if swallowed 吞食有害

Hazard Codes Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Signal word Warning

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P312
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P330 Rinse mouth. 漱口
P501 Dispose of contents/container to..… 处理内容物/容器.....

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
R20 Harmful by inhalation 吸入有害

Restrict {} 精神药品精麻类化学品

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

{hazard_c

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 44,325,1932

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 246 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PHARAT Pharmazie.  (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18,
   Berlin DDR-1020

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 450 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und
   Pharmakologie.  (Berlin, Ger.) V.110-253, 1925-66.  For publisher
   information, see NSAPCC.  Volume(issue)/page/year: 152,341,1930

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 225 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PHREA7 Physiological Reviews.  (American Physiological Soc., 9650 Rockville
   Pike, Bethesda, MD 20814)  V.1-    1921-  Volume(issue)/page/year:
   19,472,1939

{h

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 33 gm/kg
REFERENCE :
   IJMRAQ Indian Jou

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 1 gm/L
REFERENCE :
   ATSUDG Archives of Toxicology, Supplement.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  No.1-    1978-
   Volume(issue)/page/year: 4,41,1980

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 33 gm/kg
REFERENCE :
   IJMRAQ Indian Journal of Medical Research.  (Indian Council of Medical
   Research, Ansari Nagar, New Delhi 110 029, India)  V.1-    1913-
   Volume(issue)/page/year: 61,1568,1973

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 2 gm/L/48H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 12600 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 343,157,1995