CAS 57-41-0 MFCD00005264-5,5-Diphenylhydantoin 5,5-二苯基海因 TAO{mole}

5,5-Diphenylhydantoin 5,5-二苯基海因

CAS 57-41-0 MFCD00005264

化学结构图

SMILES: O=C1NC(=O)C(c2ccccc2)(c2ccccc2)N1

化学属性

Mol. Formula	C15H12N2O2
Mol. Weight	252
Melting Point	293-295 °C(lit.)
TSCA	No
Flash Point	11 °C
Solubility	DMSO 50 mg/mL Water <1 mg/mL Ethanol 13 mg/mL

别名和识别编码

Chemical Name	5,5-Diphenylhydantoin
Synonym	2,4-Imidazolidinedione, 5,5-diphenyl- 5,5-DIPHE 5,5-DIPHENYLHYDANTHOIN 5,5-DIPHENYLHYDANTOIN 5,5-Diphenyl-2,4-imidazolidinedione 5,5-Diphenylhydantoin 5,5-Diphenylimidazolidin-2,4-dione 5,5-Dwufenylohydantoina 5,5-diphenyl-hydantoi 5,5-diphenylimidazolidine-2,4-dione 5,5-二苯基乙内酰脲 5,5-二苯基海因 5,5-联苯基乙内酰脲苯妥英 5,5-二苯基海因;二苯尿囊素;5,5-联苯基乙内酰脲;二苯基乙內酰脲5,5-二苯基乙内酰脲 5,5-联苯基乙内酰脲 5,5-联苯基乙内酰脲苯妥英 5,5-联苯基乙内酰脲, 99% Aleviatin Antisacer Causoin Citrullamon Citrulliamon Comital Comitoina DIPHENYLHYDANTOIN DPH Dantoina Dantoinal klinos Dantoine Denyl Di-Hydan Di-Lan {Pu
MDL Number	MFCD00005264
CAS Number	57-41-0
Beilstein Registry Number	24,410
EC Number	200-328-6
PubChem Substance ID	1775
Merck Number	7322
Chemical Name Translation	5,5-二苯基海因
Reaxys-RN	384532
Wiswesser Line Notation	T5MVMV EHJ ER& ER
LabNetwork Molecule ID	LN00221394
InChI	InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)

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安全信息

GHS Symbol

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P310
P301+P312
P301+P312+P330
P302+P352
P307+P311
P308+P311
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P333+P313
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301 Toxic if swallowed 吞食有毒
H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H331 Toxic if inhaled 吸入中毒
H350 May cause cancer 可能致癌
H351 Suspected of causing cancer 怀疑致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H370 Causes damage to organs 导致器官损伤
H372 Causes damage to organs through prolonged or repeated exposure 长期或频繁接触会损伤器官

WGK Germany3

Signal word Danger

Personal Protective Equipment Eyeshields, Gloves, type P2 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSMU1050000

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S24 Avoid contact with skin 避免皮肤接触；
S37 Wear suitable gloves 戴适当手套；
S20 When using do not eat or drink 使用时，不得进食，饮水；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S7 Keep container tightly closed 保存在严格密闭容器中；

Risk Statements

R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
R45 May cause cancer 可能致癌
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R22 Harmful if swallowed 吞咽有害
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R11 Highly flammable 非常易燃
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Hazard Codes T T,Xn,F

Packing GroupII

Hazard Class6.1(b)

Storage condition 储存温度-20°C 2-8°C

UN Number 2811

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1620 mg/kg

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 6023 mg/kg/1Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - lymphoma, including Hodgkin's disease
   Skin and Appendages - tumors
REFERENCE :
   AJDEBP Australasian Journal of Dermatology.  (Australasian College of
   Dermatologists, 271 Bridge Rd., Glebe, N.S.W., Australia)  V.9-    1967-
   Volume(issue)/page/year: 22,28,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 52560 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-404,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   26,619,1966

TYPE OF TEST            : TDLo - Lowest published toxic

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1620 mg/kg
                          female 1-39 week(s) after conception
TOXIC

{hazard_com}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 1300 mg/kg
TOXIC EFFECTS :
   Blood - other changes
REFERENCE :
   AIMEAS Annals of Internal Medicine.  (American College of Physicians, 4200
   Pine St., Philadelphia, PA 19104)  V.1-    1927-  Volume(issue)/page/year:
   69,557,1968

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - hallucinations, distorted perceptions
   Behavioral - ataxia
REFERENCE :
   AEMED3 Annals of Emergency Medicine.  (American College of Emergency
   Physicians, 1125 Executive Circle, Irving, TX 75038)
   Volume(issue)/page/year: 16,1387,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 30,477,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 106 mg/kg/2W-I
TOXIC EFFECTS :
   Brain and Coverings - encephalitis
   Behavioral - hallucinations, distorted perceptions
   Behavioral - ataxia
REFERENCE :
   JCGADC Journal of Clinical Gastroenterology.  (Raven Press, 1185 Ave. of the
   Americas, New York, NY 10036)  V

{h

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 100 mg/L
REFERENCE :
   TIVIEQ Toxicology In Vitro.  (Pergamon Press Inc., Maxwell House, Fairview
   Park, Elmsford, NY 10523) V.1-   1987-  Volume(issue)/page/year: 2,103,1988

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 100 ug/L
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 109,961,1971

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 40 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 204,623,1988

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 1260 mg/kg/6W
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 9,387,1988

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mg/L
REFERENCE :
   VIRLAX Virology.  (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
   V.1-    1955-  Volume(issue)/page/year: 99,257,1979

TYPE OF TEST

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1620 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,481,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1080 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,702,1971

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 1365 mg/kg
SEX/DURATION            : female 1-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Effects on Newborn - physical
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   89,662,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 3675 mg/kg
SEX/DURA

其他信息

5,5-二苯基海因
苯妥英价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D0894 5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin 25G 156元 2014/06/02 D0894 5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin 500G 1380元 2010/06/21 171735000 苯妥英 5,5-Diphenylhydantoin 99+% 500 GR 1488元
海关编码:29332100
TCI Shanghai:5,5-二苯基乙内酰脲 5,5-Diphenylhydantoin,>;99.0%(T)(57-41-0)
MOL 文件:57-41-0.mol
图谱信息:苯妥英(57-41-0)红外图谱(IR1) 苯妥英(57-41-0)核磁图( 1 HNMR) 苯妥英(57-41-0)红外图谱(IR2) 苯妥英(57-41-0)核磁图( 13 CNMR) 苯妥英(57-41-0)质谱(MS)
用途一:用作抗癫痫药、抗心律失常药
上游原料:苯甲醛
下游产品:2,4,6-三氟苯酚
Alfa Aesar:5,5-联苯基乙内酰脲,99% 5,5-Diphenylhydantoin, 99%(57-41-0)
Sigma Aldrich:57-41-0(sigmaaldrich)
Acros Organics:5，5-二苯基海因 5,5-Diphenylhydantoin, 99+%(57-41-0)
MSDS 信息:5,5-Diphenyl-2,4-imidazolidinedione(57-41-0).msds