Ethyl 4-((6-Guanidinohexanoyl)Oxy)Benzoate Methanesulfonate 加贝酯甲磺酸盐
CAS 56974-61-9 MFCD00210299
化学结构图
SMILES: CCOC(=O)C1C=CC(=CC=1)OC(=O)CCCCCNC(N)=N.CS(O)(=O)=O
化学属性
| Mol. Formula | C17H27N3O7S |
|---|---|
| Mol. Weight | 417 |
| Melting Point | 91 |
别名和识别编码
| Chemical Name | Ethyl 4-((6-Guanidinohexanoyl)Oxy)Benzoate Methanesulfonate |
|---|---|
| Synonym | 4-(6-胍基己酰氧基)苯甲酸乙酯甲磺酸盐 4-[[6-[(氨基亚氨基甲基)氨基]-1-氧己基]氧]苯甲酸乙酯 甲磺酸盐 福耶 Ethyl p-(6-guanidinohexanoyloxy) benzoate methanesulfonate FOY Gabexate Methanesulfonate Gabexate mesilate p-Hydroxybenzoic acid ethyl ester 6-guanidinohexanoate mesilate 甲磺酸加贝酯 |
| MDL Number | MFCD00210299 |
| Chemical Name Translation | 加贝酯甲磺酸盐 |
| CAS Number | 56974-61-9 |
| Reaxys-RN | 5702026 |
| Merck Number | 4320 |
| PubChem Substance ID | 253660880 |
| Beilstein Registry Number | 5702026 |
| Wiswesser Line Notation | MUYZM5VOR DVO2 &WSQ1 |
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分类
- {SNA} A to C,
- {SNA} A to C, Additional Drugs, Additional Standards, Analytical Standards, Chemical Structure, Chromatography, Chymotrypsin, α-, Chymotrypsin, alpha-, Coagulation Proteins and Reagents, D to K, Drugs of Abuse, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Forensic and Veterinary Standards, Inhibitors, Kallikrein, Plasma, Others, P to Q, Pharmaceuticals, Illicit Drugs & Alcohol, Plasma & Blood Proteins, Plasmin, Protease Inhibitor Specificity Index, Protease Inhibitors, R to Z, Thrombin,
相关文献及参考
- [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5.
- [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated diseases, on the nitric oxide pathway. Biochem Biophys Res Commun, 1998. 246(2): p. 453-6.
- [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6.
- [1]. Erba, F., et al., Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug. Biochem Pharmacol, 2001. 61(3): p. 271-6.
- [2]. Aosasa, S., et al., Mechanism of the inhibitory effect of protease inhibitor on tumor necrosis factor alpha production of monocytes. Shock, 2001. 15(2): p. 101-5.
- [3]. Colasanti, M., et al., Effect of gabexate mesylate (FOY), a drug for serine proteinase-mediated
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P273 Avoid release to the environment. 避免释放到环境中。
- P301+P312
- P330 Rinse mouth. 漱口
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 6480 mg/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,743,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 4020 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,743,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 8 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Gastrointestinal - changes in structure or function of salivary glands REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 9,743,1975
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 79 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/p
