N-Methyl-3-Phenyl-3-(4-(Trifluoromethyl)Phenoxy)Propan-1-Amine Hydrochloride N-甲基-3-(对三氟甲基苯氧基)-3-苯基丙胺盐酸盐
CAS 56296-78-7 MFCD00214288
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分类
- {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Cell Signaling Enzymes, Eli Lilly, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Inhibitors,
- {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors,
- {SNA} Application Index,
- {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Cell Signaling Enzymes, Eli Lilly, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
- {SNA} APIs & Metabolites,
- {SNA} Application Index,
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P301+P312+P330
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H318 Causes serious eye damage 严重伤害眼睛
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
- H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
- H302+H332
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S39 Wear eye/face protection 戴眼睛/面孔保护装置;
- R50 Very toxic to aquatic organisms 对水生生物极毒
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 17 mg/kg/2W-I TOXIC EFFECTS : Behavioral - anorexia (human) REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 55,118,1994
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 452 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE :
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : >250 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 46(3,Sec 2),7,1985
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE/DURATION : 13600 ug/kg TOXIC EFFECTS : Skin and Appendages - dermatitis, allergic (after systemic exposure) Skin and Appendages - dermatitis, irritative (after systemic exposure) REFERENCE : JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982- Volume(issue)/page/year: 27,389,1989
TYPE OF TEST : LD - Lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Primate - monkey DOSE/DURATION : >50 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JCLPDE Journal of Cl
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - man DOSE : 26 mg/kg SEX/DURATION : male 45 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - other effects on male REFERENCE : JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978- Volume(issue)/page/year: 53,119,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE : 80 mg/kg SEX/DURATION : female 13-20 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 269,637,1994
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 84 mg/kg SEX/DURATION : female 7-21 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - skin and skin appendages REFERENCE : PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Human - woman DOSE : 190 ug/kg SEX/DURATION : female 1-90 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - abortion REFERENCE : JAMAAP JAMA, Journal of th