N-Methyl-3-Phenyl-3-(4-(Trifluoromethyl)Phenoxy)Propan-1-Amine Hydrochloride N-甲基-3-(对三氟甲基苯氧基)-3-苯基丙胺盐酸盐

CAS 56296-78-7 MFCD00214288

化学结构图

56296-78-7
SMILES: Cl.CNCCC(OC1C=CC(=CC=1)C(F)(F)F)C1C=CC=CC=1

化学属性

Mol. FormulaC17H18F3NO·HCl
Mol. Weight346
Melting Point157-161

别名和识别编码

Chemical NameN-Methyl-3-Phenyl-3-(4-(Trifluoromethyl)Phenoxy)Propan-1-Amine Hydrochloride
CAS Number56296-78-7
Alfabeta NameFLUOXETINEHYDROCHLORIDE
MDL NumberMFCD00214288
Synonym 氟西汀 盐酸盐 Fluoxetine hydrochloride (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯基丙胺 盐酸盐 Fluoxetine HCl LY-110,140 盐酸盐 Prozac® (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯基丙胺 盐酸盐 Prozac® Lilly 110140 (+-)-Methyl-gamma-(4-(trifluoromethyl)phenoxy)benzenepropanamine LY-110,140 盐酸盐 (±)-N-甲基-γ-[4-(三氟甲基)苯氧基]苯基丙胺 盐酸盐 LY-110,140 盐酸盐 Prozac® Fontex Fluoxetine HCl
PubChem Substance ID125307843
EC Number260-101-2
Chemical Name TranslationN-甲基-3-(对三氟甲基苯氧基)-3-苯基丙胺盐酸盐
Reaxys-RN6759273
Wiswesser Line NotationFXFFR DOYR&2M1 &GH
Beilstein Registry Number6759273
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分类

  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Cell Signaling Enzymes, Eli Lilly, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Inhibitors,
  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors,
  • {SNA} Application Index,
  • {SNA} Application Index, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biogenic Amine Transport Inhibitors, Cell Signaling Enzymes, Eli Lilly, F, GPCR Modulators, GPCR Proteins, Modulators and Antibodies,
  • {SNA} APIs & Metabolites,
  • {SNA} Application Index,

安全信息

Warnings IRRITANT
RTECSUI4050000
GHS Symbol
Precautionary statements
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
Hazard statements
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H318 Causes serious eye damage 严重伤害眼睛
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
  • H302+H332
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
WGK Germany3
Signal word
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中,参考特别指示/安全收据说明书;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
Hazard Codes
Risk Statements
  • R50 Very toxic to aquatic organisms 对水生生物极毒
  • R22 Harmful if swallowed 吞咽有害
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Hazard Class9
UN Number
Packing GroupIII
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 17 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - anorexia (human)
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 55,118,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 452 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 46(3,Sec 2),7,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 13600 ug/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, allergic (after systemic exposure)
   Skin and Appendages - dermatitis, irritative (after systemic exposure)
REFERENCE :
   JTCTDW Journal of Toxicology, Clinical Toxicology.  (Marcel Dekker, 270
   Madison Ave., New York, NY 10016)  V.19-    1982-  Volume(issue)/page/year:
   27,389,1989

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >50 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JCLPDE Journal of Cl

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE                    : 26 mg/kg
SEX/DURATION            : male 45 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - other effects on male
REFERENCE :
   JCLPDE Journal of Clinical Psychiatry.  (Physicians Postgraduate Press,
   Inc., POB 240008, Memphis, TN 38124)  V.39-    1978-
   Volume(issue)/page/year: 53,119,1992

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 80 mg/kg
SEX/DURATION            : female 13-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 269,637,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 84 mg/kg
SEX/DURATION            : female 7-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - skin and skin
   appendages
REFERENCE :
   PBBHAU Pharmacology, Biochemistry and Behavior.  (ANKHO International Inc.,
   P.O. Box 426, Fayetteville, NY 13066)  V.1-    1973-

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 190 ug/kg
SEX/DURATION            : female 1-90 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   JAMAAP JAMA, Journal of th

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