CAS 562-10-7 MFCD00056168-N,N-Dimethyl-2-(1-Phenyl-1-(Pyridin-2-Yl)Ethoxy)Ethanamine Succinate N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐 TAO{mole}

N,N-Dimethyl-2-(1-Phenyl-1-(Pyridin-2-Yl)Ethoxy)Ethanamine Succinate N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐

CAS 562-10-7 MFCD00056168

化学结构图

SMILES: CN(C)CCOC(C)(c1ccccc1)c1ccccn1.O=C(O)CCC(=O)O

化学属性

Mol. Formula	C17H22N2O
Mol. Weight	388
Solubility	DMSO 78 mg/mL Water 78 mg/mL Ethanol 78 mg/mL
Stability	对光线敏感
Melting Point	109.0 to 113.0 deg-C

别名和识别编码

Chemical Name	N,N-Dimethyl-2-(1-Phenyl-1-(Pyridin-2-Yl)Ethoxy)Ethanamine Succinate
MDL Number	MFCD00056168
CAS Number	562-10-7
EC Number	209-228-7
Synonym	2-(alpha-(2-(dimethylamino)ethoxy)-alpha-methylbenzyl)-pyridinsuccinate(1 2-(alpha-(2-Dimethylaminoethoxy)-alpha-methylbenzyl)pyridine succinate 2-(alpha-(2-dimethylaminoethoxy)-alpha-methylbenzyl)pyridinesuccinate 2-Dimethylaminoethoxyphenylmethyl-2-picoline succinate 2-dimethylaminoethoxyphenylmethyl-2-picolinesuccinate Alsadorm Butanedioic acid, compd. with N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine (1:1) DOXYLAMINE SUCCINATE DOXYLAMINE SUCCINATE SALT DOXYLAMINESUCCINATE,USP Decapryn Decapryn succinate Decarpyn succinate (1:1) Dimethylaminoethoxy-methyl-benzyl-pyridine succinate Doxylamine succinate (1:1) Doxylamine succinate salt Gittalun Hoggar N LABOTEST-BB LT00244822 Mereprine N,N-DIMETHYL-2-[1-PHENYL-1-(2-PYRIDINYL)ETHOXY]ETHENAMINE SUCCINATE N,N-Dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine succinate N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐 Phenyl2-pyridylmethyl-beta-N,N-dimethylaminoethyl ether succinate Sedaplus Unisom alsadorm decapryn decarpynsuccinate(1:1) dimethylaminoethoxy-methyl-benzyl-pyridinesuccinate doxylaminesuccinate(1:1) gittalun hoggarn mereprine phenyl2-pyridylmethyl-beta-n,n-dimethylaminoethylethersuccinate sedaplus unisom 多西拉敏琥珀酸酯琥珀酸多西拉敏琥珀酸多西拉敏; N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐
PubChem Substance ID	11224
Chemical Name Translation	N,N-二甲基-2-[1-苯基-1-(2-吡啶)乙氧基]乙胺琥珀酸盐
Wiswesser Line Notation	T6NJ BX1&R&O2N1&1 &OV2VO
LabNetwork Molecule ID	LN01299816
Merck Number	3441
InChI	InChI=1S/C17H22N2O.C4H6O4/c1-17(20-14-13-19(2)3,15-9-5-4-6-10-15)16-11-7-8-12-18-16;5-3(6)1-2-4(7)8/h4-12H,13-14H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

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分类

{SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Signaling and Neuroscience, DIG-DY, GPCR Modulators,
{SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, DIG-DY, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Sanofi Aventis, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学,

安全信息

Hazard Codes 9

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害

WGK Germany3

GHS Symbol

Precautionary statements

P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312
P301+P312+P330
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H332 Harmful if inhaled 吸入有害
H302 Harmful if swallowed 吞食有害
H312 Harmful in contact with skin 皮肤接触有害

RTECSUS9275000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Storage condition <0°C 储存温度-20°C 储存温度2-8°C

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65520 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,311,1993

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 87600 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   JACTDZ Journal of the American College of Toxicology.  (Mary Ann Liebert,
   Inc., 1651 Third Ave., New York, NY 10128)  V.1-12, 1982-1993. Discontinued.
    Volume(issue)/page/year: 12,1,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 33,325,1948

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - food intake (animal)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 37,311,1948

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 470 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/y

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 62 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JLCMAK Journal of Laboratory and Clinical Medicine.  (C.V. Mosby Co., 11830
   Westline Industrial Dr., St. Louis, MO 63141)  V.1-    1915-
   Volume(issue)/page/year: 33,325,1948

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 500 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 135,131,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 765 mg/kg
SEX/DURATION            : female 20-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 13,225,1985

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Primate - monkey
DOSE                    : 1710 mg/kg
SEX/DURATION            : female 20-35 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IMSCE2 IRCS Medical Science.  (Lancaster, UK)  V.12-14, 1984-86.  For
   publisher information, see MSCREJ.  Volume(issue)/page/year: 13,225,1985

UN Number 3077

Packing GroupIII

其他信息

Doxylamine succinate竞争性抑制组胺H1受体，具有镇静和抗胆碱作用。
MOL 文件:562-10-7.mol
Sigma Aldrich:562-10-7(sigmaaldrich)
Doxylamine succinate