CAS 56-49-5 MFCD00003704-3-Methylcholanthrene 3-甲基胆蒽 TAO{mole}

3-Methylcholanthrene 3-甲基胆蒽

CAS 56-49-5 MFCD00003704

化学结构图

SMILES:

化学属性

Mol. Formula	C21H16
Mol. Weight	268
Boiling Point	280 °C/80 mmHg(lit.)
Melting Point	178-180 °C(lit.)
Density	1.0
Flash Point	-5 °C

别名和识别编码

Chemical Name	3-Methylcholanthrene
CAS Number	56-49-5
Synonym	{uni_hamburg} cholanthrene, 3-methyl- 3-mch 3-MC 3-甲基胆蒽 Methylcholanthrene 3-甲基胆蒽溶液 3-methylbenz(j)aceanthrene 3-methyl-cholanthrene 1,2-Dihydro-3-methylbenz(j)aceanthrylen 3-Methylcholanthrene-(20) 3-METHYLCHOLANTHRENE 20-Methylcholanthrene 3-meca MCA 1,2-Dihydro-3-methyl-benz[j]aceanthrylene 20-methylchlolanthrene 3-Methyl-cholanthren (20) 3-Methyl-1,2-dihydrobenzo[j]aceanthrylene 3-methylcholanthren 20-METHYLCHOLANTHRENE 1,2-dihydro-3-methyl-benz[j]aceanthrylen 1,2-dihydro-3-methyl-benz(j)aceanthrylen 3-MCA RCRA waste number U157 3-Methoxycholanthrene 3-methyl-i,j-cyclopentabenz(a)anthracene 3-methyl-cholanthren Benz(j)aceanthrylene, 1,2-dihydro-3-methyl- 3-Methylcholanthrene (20) 3-Methylcholanthren (20-) 3-甲基胆蒽溶液 3-methylcholanthrene 3-methylcyclopentabenzophenanthrene 20-MC Benz[j]aceanthrylene, 1,2-dihydro-3-methyl- 2O-Methylcholanthren 3-Methylcholanthrene benz[j]aceanthrylene, 1,2-dihydro-3-methyl- 甲基膽蒽 1,2-dihydro-3-methylbenz[j]aceanthrylene
MDL Number	MFCD00003704
PubChem Substance ID	57647926
EC Number	200-276-4
Beilstein Registry Number	1913890
Chemical Name Translation	3-甲基胆蒽
Merck Number	13,6072
Wiswesser Line Notation	L E6 D6656 1A T&&&T&J R1
LabNetwork Molecule ID	LN01301455

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

致癌物质，常用来诱导培养细胞的转化；在实验动物身上诱导纤维肉瘤和皮肤癌。

安全信息

GHS Symbol

WGK Germany3

Hazard statements

H332 Harmful if inhaled 吸入有害
H319 Causes serious eye irritation 严重刺激眼睛
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H312 Harmful in contact with skin 皮肤接触有害
H302 Harmful if swallowed 吞食有害
H350 May cause cancer 可能致癌
H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Precautionary statements

P308+P313
P201 Obtain special instructions before use. 使用前获取专门指示。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P305+P351+P338

Signal word Danger

RTECSFZ3675000

Hazard Codes T F,Xn T,Xn,F

Risk Statements

R45 May cause cancer 可能致癌
R53 May cause long-term adverse effects in the aquatic environment 对水生环境有长期的有害作用
R36 Irritating to eyes 刺激眼睛
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R11 Highly flammable 非常易燃

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Storage condition 储存温度2-8°C 2-8°C

Packing GroupIII

Hazard Class6.1(b)

UN Number 2811

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 ug/kg
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher infor

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 20 mg/kg/15D-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   22,1155,1962

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 22 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   29,1927,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   JCROD7 Journal of Cancer

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   23,288,1972

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intrapleural
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >40 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   BAFEAG Bulletin de l'Association Francaise pour l'Etude du Cancer.  (Paris,
   France)  V.1-52, 1908-65. For publisher information, see BUCABS.
   Volume(issue)/page/year: 27,706,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intrarenal
SPECIES OBSERVED        : Amphibian - frog
DOSE/DURATION           : 9 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   24,1969,1964

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intravenous
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 50 mg/kg
REFERENCE :
   GANNA2 Gann.  Japanese Journal of Cancer Research.  (Tokyo, Japan)  V.1-75,
   1907-84.  For publisher information, see JJCREP.  Volume(issue)/page/year:
   64,637,1973

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 750 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

{h

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - rat Embryo
DOSE/DURATION           : 1 ug/L
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere P

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Fish - not otherwise specified Cells - not otherwise
                          specified
DOSE/DURATION           : 1 mg/L/48H
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 4,181,1982

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 74,107,1980

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 20 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 74,113,1980

{haz

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 189 mg/kg
SEX/DURATION            : female 15-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   72,417,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 64 mg/kg
SEX/DURATION            : female 9-21 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   26,567,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 50 mg/kg
SEX/DURATION            : female 19-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   73,457,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 70 mg/kg
SEX/DURATION            : female 7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproduc

其他信息

Sigma Aldrich:56-49-5(sigmaaldrich)
用途一:致癌物质，常用来诱导培养细胞的转化；在实验动物身上诱导纤维肉瘤和皮肤癌。
3-甲基胆蒽价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 S21394201 3-甲基胆蒽 98％ 100mg 2689元
MOL 文件:56-49-5.mol