Deoxycorticosterone Acetate 醋酸去氧皮质酮
CAS 56-47-3 MFCD00003660
化学结构图
SMILES:
化学属性
| Mol. Formula | C23H32O4 |
|---|---|
| Mol. Weight | 372.51 |
| Melting Point | 156.0 to 162.0 deg-C |
| Appearance | +168°-+176°(二氧六环)、+179°-+184°(1%，乙醇)；乙醇溶液在240nm波长处有最大吸收。本品溶于氯仿(1：1.5)、丙酮(1：30)、乙醇 (1：50)，微溶于乙醚(1：170)，几乎不溶于水。 白色结晶性粉末，无臭、无味。在空气中稳定。Mp158-161℃；比旋光度[α] D 20 |
| Solubility | Soluble in methanol, ethanol (6 mg/mL at 25 °C), chloroform (100 mg/mL), and DMSO (11 mg/mL at 25 °C). Insoluble in water. |
| Refractive index | 175 ° (C=1, Dioxane) |
别名和识别编码
| Chemical Name | Deoxycorticosterone Acetate |
|---|---|
| CAS Number | 56-47-3 |
| Alfabeta Name | DIOXOPREGNENYLACETATE 320421-----, |
| MDL Number | MFCD00003660 |
| Synonym | 醋酸去氧皮质酮; 11-去氧皮质酮乙酸酯; 21-乙酰氧基孕甾-4-烯-3,20-二酮; 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯; 21-羟基孕酮-21-乙酸酯; DOC 乙酸酯 Unidocan 11-Desoxycorticosterone acetate; 21-Acetoxy-4-pregnene-3,20-dione; 21-Hydroxy-4-pregnene-3,20-dione 21-acetate; 4-Pregnen-21-ol-3,20-dione 21-acetate; Cortexone acetate Percotol Corticost 21-HYDROXY-4-PREGNENE-3,20-DIONE 21-ACETATE Decortin {Chemicalbook} Syncort 乙酸脱氧皮质甾酮 4-Pregnene-3,20-dione-21-ol acetate Dorcostrin 4-PREGNEN-21-OL-3,20-DIONE ACETATE DESOXYCORTICOSTERONE ACETATE ######## DOC acetate DELTA4-PREGNEN-21-OL-3, 20-DIONE ACETA Cortenil Cortesan 21-ACETOX 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯 醋酸脱氧皮质酮 11-去氧皮质酮乙酸酯 21-乙酰氧基孕甾-4-烯-3,20-二酮 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯 Krinocorts 21-Acetoxy-3,20-diketopregn-4-ene Cortixyl 21-Hydroxypregn-4-ene-3,20-dione 21-acetate Desoxycorticosterone acetate 乙酸-11-脱氧皮质甾酮 11-desoxycorticosterone acetate 醋酸去氧皮质酮 Cortivis DCA 11-去氧皮质酮乙酸酯 21-乙酰氧基孕甾-4-烯-3,20-二酮 21-羟基孕甾-4-烯-3,20-二酮-21-醋酸酯 21-羟基孕酮-21-乙酸酯 DOC 乙酸酯 乙酸脱氧肾上腺皮质固酮 孕甾-4-烯-21-醇-3,20-二酮-21-醋酸酯 脱氧皮质酮醋酸酯 Percorten 11-DEOXYCORTICOSTERONE ACETATE Cortiron 11-deoxycorticosterone21-acetate 乙酸脱氧皮质酮 Primocort 21-乙酰氧基孕甾-4-烯-3,20-二酮 { Cortate 21-Acetyloxypregn-4-ene-3,20-dione DOCA 脱 孕甾-4 {Che {haz {Chemicalbook Cortexone acetat Organon's Doca Acetate Doxycamon Syncortyl 21-HYDR |
| PubChem Substance ID | 24894065 |
| Beilstein Registry Number | 2570798 |
| EC Number | 200-275-9 |
| Chemical Name Translation | 醋酸去氧皮质酮 |
| Merck Number | 2901 |
| Wiswesser Line Notation | L E5 B666 OV MUTJ A F FV1OV1 |
| LabNetwork Molecule ID | LN00159825 |
| Reaxys-RN | 2570798 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SNA} Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones, 细胞生物学
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
- {Chemicalbook} 生物化学品: 生化试剂: 激素
- Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Steroid Hormones
- {SA} Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Complex Molecules
- {SNA} Bioactive Small Molecule Alphabetical Index, Corticosteroid, Cytokines, Growth Factors and Hormones, D-DIF,
产品应用
- Adrenocortical/mineralocorticoid Steroid.
相关文献及参考
- Quigley, J., et al.: Clin. Exper. Pharmacol. Physiol., 36, 724 (2009),
- Merck 14 ,2901
- Beil. 8 ,IV,2195
- FT-NMR 1 (3), 602:C / Structure Index 1 , 460:D:5
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 520 mg/kg/13W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 83,14,1953
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - rat DOSE : 16 mg/kg SEX/DURATION : male 2 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles) REFERENCE : ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939- Volume(issue)/page/year: 24(Suppl 3),1,1963
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE : 316 mg/kg
SEX/DURATION : female 56 day(s) pre-mating
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 120,238,1965TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rat DOSE : 224 mg/kg SEX/DURATION : female 56 day(s) pre-mating TOXIC EFFECTS : Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated) REFERENCE : PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 120,238,1965
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - rat DOSE
其他信息
- 下游产品:21-羟基-5α-孕甾(烷)-3,20-二酮
- MSDS 信息:21-Hydroxy-4-pregnene-3,20-dione 21-acetate(56-47-3).msds
- Sigma Aldrich:56-47-3(sigmaaldrich)
- TCI Shanghai:乙酸去氧皮质酮 Deoxycorticosterone Acetate,>;98.0%(LC)(56-47-3)
- 用途一:生化研究，肾上腺皮质激素类药物，具有抗炎、抗过敏等作用。
- Deoxycorticosterone acetate是一种类固醇激素，用于肌肉注射，是肾上腺皮质类固醇的代替疗法。
- 上游原料:四氢呋喃 --> 氧化钙 --> 乙酸钾 --> 孕酮 --> 无水丙酮
- 醋酸去氧皮质酮
- 参考质量标准:含量达96.0%-104.0%，mp157-161℃；比旋光度[α] 20 D +179°-+184°；吸光度(A)0.43-0.45(0.001%，240nm)；检测氟化物、干燥失重及灰分等杂质含量。
- 方法一:黄体酮在四氢呋喃和甲醇混合溶液中与氧化钙和碘发生碘代反应，再与醋酸钾在无水丙酮中反应成酯，最后精制而得。
- 用途二:羟孕酮琥酯钠的中间体。
- MOL 文件:56-47-3.mol
