CAS 55-98-1 MFCD00007562-Busulfan 白消安 TAO{mole}

Busulfan 白消安

CAS 55-98-1 MFCD00007562

化学结构图

SMILES: CS(=O)(=O)OCCCCOS(C)(=O)=O

化学属性

Mol. Formula	C6H14O6S2
Mol. Weight	246
Melting Point	114.0 to 118.0 deg-C
Solubility	Decomposes

别名和识别编码

Chemical Name	alpha-Lobeline hydrochloride
Synonym	1,4-Bis(methane-sulponyloxy)butane 1,4-Dimethylsulfonoxybutane 1,4-bis(methanesulfonoxy)butane 1,4-dimesyloxybutane 1,4-dimethanesulfonoxybutane 1,4-dimethanesulphonyloxybutane 1,4-dimethylsulfonyloxybutane 1,4-丁二醇二甲烷磺酸盐 1,4-丁二醇二甲烷磺酸盐白消安 1,4-丁二醇二甲烷磺酸盐;二甲磺酸-1,4-丁二醇;二甲磺酸丁酯; 1，4-Butanediol dimethyl sulfonate Busulfan Busulfan Wellcome Busulfex Busulphan Glyzophrol Mabli Mielosan Milecitan Miler Myeloleukon Myelosan Mylecytan Myleran Myléran Tetramethylene bis(methanesulfonate) Tetramethylenester kyseliny methansulfonove Wellcome, Busulfan X 149 busulfex n-Butane-1,3-di(methylsulfonate)
Beilstein Registry Number	1791786
PubChem Substance ID	2478
CAS Number	55-98-1
EC Number	200-250-2
MDL Number	MFCD00007562
Chemical Name Translation	白消安
Reaxys-RN	1791786
Merck Number	1505
Wiswesser Line Notation	WS1&O4OSW1
LabNetwork Molecule ID	LN00239479
InChI	InChI=1S/C6H14O6S2/c1-13(7,8)11-5-3-4-6-12-14(2,9)10/h3-6H2,1-2H3

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安全信息

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P301+P310+P330
P301+P316
P302+P350
P302+P352
P302+P352+P312+P361+P364
P304+P340
P304+P340+P311
P305+P351+P338
P308+P313
P308+P316
P309+P311
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P318
P319
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P337+P313
P337+P317
P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
P361+P364
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSEK1750000

GHS Symbol

Signal word

Hazard statements

H300 Fatal if swallowed 吞食致命
H301 Toxic if swallowed 吞食有毒
H301+H311+H331
H310 Fatal in contact with skin 皮肤接触致命
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H330 Fatal if inhaled 吸入致命
H335 May cause respiratory irritation 可能导致呼吸道刺激
H340 May cause genetic defects 可能导致遗传性缺陷
H350 May cause cancer 可能致癌
H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官

Hazard Codes T+,T T+

WGK Germany3

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；

Risk Statements

R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R45 May cause cancer 可能致癌
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R46 May cause inheritable genetic damage 可能引起遗传基因损害
R23/25 Toxic by inhalation and if swallowed 吸入及吞食都有毒

UN Number UN 2811 6.1/PG 1 2811

Packing GroupIII

Hazard Class6.1

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   33,3069,1973

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg/42D-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Blood - leukemia
   Blood - lymphoma, including Hodgkin's disease
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   25,20,1965

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 1140 mg/kg/9Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
   AIMDAP Archives of Internal Medicine.  (AMA, 535 N. Dearborn St., Chicago,
   IL 60610)  V.1-    1908-

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 16720 ug/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Reproductive - Tumorigenic effects - uterine tumors
REFERENCE :
   JCROD7 Journal of Cancer Research and Clinical Oncology.  (Springer-Verlag
   New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   6,160,1952

TYPE OF TEST            : LD50 - Le

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 8 mg/kg/2D-I
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 2,1463,1984

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 8 mg/kg
TOXIC EFFECTS :
   Blood - leukopenia
   Blood - agranulocytosis
   Blood - other changes
REFERENCE :
   CCSUBJ Cancer Chemotherapy Reports, Part 2.  (Washington, DC)  V.1-5,
   1964-75.  For publisher information, see CTRRDO.  Volume(issue)/page/year:
   2,203,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - ra

TYPE OF TEST            :

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHABA8 Chemical Abstracts.  (Chemical Abstracts Service, Box 3012, Columbus,
   OH  43210) V.1-    1907-  Volume(issue)/page/year: 55,10679a,1961

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Implant
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 600 mg/kg
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 90 umol/L
REFERENCE :
   EVSRBT Environmental Science Research.  (Plenum Pub. Corp., 233 Spring St.,
   New York, NY 10013) V.1-    1972-  Volume(issue)/page/year: 24,175,1981

TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - not otherwise specified
DOSE/DURATION           : 30 ug
REFERENCE :
   ABABAC Annales de Biologie Animale, Biochimie, Biophysique.  (Versailles,
   France)  V.1-19, 1961-79.  Volume(issue)/page/year: 17,661,1977

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 10 mmol/L
REFERENCE :
   JOGNAU Journal of Genetics.  (Belghoria, India)  V.1-63, 1910-77.
   Discontinued.  Volume(issue)/page/year: 54,146,1956

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Unreported
TEST SYSTEM             : Human - woman
DOSE/DURATION           : 138 mg/kg
REFERENCE :
   GRM

TYPE OF TEST            : Heritable translocation test
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1 ppb
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   23,208,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 5280 ug/kg
SEX/DURATION            : female 14-26 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - gastrointestinal
   system
REFERENCE :
   AJOGAH American Journal of Obstetrics and Gynecology.  (C.V. Mosby Co.,
   11830 Westline Industrial Dr., St. Louis, MO 63146)  V.1-    1920-
   Volume(issue)/page/year: 92,580,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE                    : 17 mg/kg
SEX/DURATION            : female 4-36 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - urogenital system
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   PEDIAU Pediatrics.  (American Academy of Pediatrics, P.O. Box 1034,
   Evanston, IL 60204) V.1-    1948-  Volume(issue)/page/year: 25,85,1960

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 30(1),14A,1984

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 40 mg/kg
SEX/DURATION            : mal

其他信息

MOL 文件:55-98-1.mol
类别:有毒物质
可燃性危险特性:热分解排出有毒硫氧化物烟雾
上游原料:甲基磺酰氯 --> 1,4-丁二醇
白消安价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 B1022 1,4-丁二醇二甲烷磺酸盐 1,4-Butanediol Dimethanesulfonate 25G 630元 2010/06/21 306520250 白消安 Busulfan 98% 25 GR 686元
方法一:由甲基磺酰氯与1,4-丁二醇缩合而得。
毒性分级:高毒
Sigma Aldrich:55-98-1(sigmaaldrich)
外观性质:白色结晶。
急性毒性:腹腔-大鼠 LD50: 22 毫克/公斤; 口服-小鼠 LD50: 110 毫克/公斤
灭火剂:水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
MSDS 信息:1,4-双甲基磺氧基丁烷(55-98-1).msds
储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放; 不易久储, 以防聚合
Acros Organics:白消安 Busulfan, 98%(55-98-1)
TCI Shanghai:二甲磺酸-1,4-丁二醇 1,4-Butanediol Dimethanesulfonate,>;97.0%(T)(55-98-1)
用途一:抗肿瘤药。该品为细胞周期非特异性药物，主要用于G1期和M期。该品低剂量抑制骨髓粒细胞的生成，对红细胞和淋巴细胞几乎无影响。大剂量时对红细胞和淋巴细胞几乎无影响。大剂量时对红细胞和淋巴细胞的生成起抑制作用。由于选择性作用，对慢性粒细胞白血病疗效显著。白消安为目前治疗慢性粒细胞白血病的主要药物，其缓解率可达80-90%。但一旦发生急性变时应停药。