5-Methyl-1H-indole-3-carbaldehyde 5-甲基-1H-吲哚-3-甲醛

CAS 52562-50-2 MFCD00022720

化学结构图

52562-50-2
SMILES: CC1=CC2C(C=O)=CNC=2C=C1

化学属性

Mol. FormulaC10H9NO
Mol. Weight159
Melting Point148-151 °C(lit.)

别名和识别编码

Chemical Name5-Methyl-1H-indole-3-carbaldehyde
CAS Number52562-50-2
Alfabeta NameMETHYLINDOLECARBALDEHYDE H513-----
MDL NumberMFCD00022720
Synonym 5-甲基-1H-吲哚-3-甲醛 NSC 88872
PubChem Substance ID24848132
Chemical Name Translation5-甲基-1H-吲哚-3-甲醛
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分类

  • {SNA} Aldehydes, Building Blocks, C10, C10-C12, Carbonyl Compounds, Chemical Synthesis, Heterocyclic Building Blocks, Indoles, Organic Building Blocks
  • Aldehydes, Building Blocks, C10, C10-C12, Carbonyl Compounds, Chemical Synthesis, Heterocyclic Building Blocks, Indoles, Organic Building Blocks

相关文献及参考

  • 2. Al-Tel, T. H.; et al., Design, synthesis and in vitro antimicrobial evaluation of novel Imidazo[1,2-a]pyridine and imidazo[2,1-b][1,3]benzothiazole motifs Eur. J. Med. Chem. 46 , 1874, (2011)
  • 3. Thirupathi R. Y.; et al., Aplysinopsin analogs: synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones Bioorg. Med. Chem. 18 , 3570, (2010)
  • 4. Zhou, J.; et al., Synthesis and in vitro characterization of ionone-based chalcones as novel antiandrogens effective against multiple clinically relevant androgen receptor mutants Invest. New Drugs 28 , 391, (2010) 摘要
  • 5. Penthala, N. R.; et al., Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines Bioorg. Med. Chem. Lett. 20 , 591, (2010)
  • 8. Sonar, V. N.; et al., Novel substituted (Z)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-one and (Z)-(±)-2-(N-benzylindol-3-ylmethylene)quinuclidin-3-ol derivatives as potent thermal sensitizing agents Bioorg. Med. Chem. Lett. 17 , 6821, (2007)
  • 9. Diana, P.; et al., Synthesis and antitumor properties of 2,5-bis(3'-indolyl)thiophenes: Analogues of marine alkaloid nortopsentin Bioorg. Med. Chem. Lett. 17 , 2342, (2007)
  • 10. Harada, H.; et al., Novel and potent human and rat ß3-adrenergic receptor agonists containing substituted 3-indolylalkylamines Bioorg. Med. Chem. Lett. 13 , 1301, (2003)
  • Dolusic, E.; et al., Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators J. Med. Chem. 54 , 5320, (2011) 摘要
  • Noeren-Mueller, A.; et al., Discovery of a new class of inhibitors of Mycobacterium tuberculosis prote

安全信息

Warnings IRRITANT
WGK Germany3
GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes Xi
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

系列性分类


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