CAS 522-48-5 MFCD00058029-Tetrahydrozoline Hydrochloride 四氢唑啉盐酸盐 TAO{mole}

Tetrahydrozoline Hydrochloride 四氢唑啉盐酸盐

CAS 522-48-5 MFCD00058029

化学结构图

SMILES: Cl.c1ccc2c(c1)CCCC2C1=NCCN1

化学属性

Mol. Formula	C13 H16 N2 . Cl H
Mol. Weight	236.74

别名和识别编码

Chemical Name	Tetrahydrozoline Hydrochloride
CAS Number	522-48-5
Synonym	1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, 2-(1,2,3,4-Tetrahydro-1-Naphthylamino)-2-ImidazolineHydrochloride 2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride 2-(1,2,3,4-Tetrahydronaphthalene-1-yl)-4,5-dihydro-1H-imidazole·hydrochloride 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinehydrochloride 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinemonohydrochloride 2-(1,2,3,4-tetrahydro-1-naphthyl)-2-imidazolinhydrochloride 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole Hydrochloride 4,5-Dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1H-imidazole monohydrochloride Tetryzoline hydrochloride 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazo 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-1h-imidazolmonohydroch
MDL Number	MFCD00058029
PubChem Substance ID	10648
EC Number	208-329-3
Chemical Name Translation	四氢唑啉盐酸盐
Wiswesser Line Notation	L66&TJ G- BT5M CN BUTJ &GH
InChI	InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
LabNetwork Molecule ID	LN00335760

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分类

{SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Novartis, T, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
Pharmaceut
{SNA} Adrenergics,
{SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,

产品应用

An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.

安全信息

WGK Germany3

GHS Symbol

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H335 May cause respiratory irritation 可能导致呼吸道刺激
H302 Harmful if swallowed 吞食有害
H319 Causes serious eye irritation 严重刺激眼睛

RTECSNJ4550000

Signal word Warning

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn Xn,Xi Xi

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 245 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,495,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 110 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,
   Ont., Canada)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXP

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 122 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   J

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Bird - domestic
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CLDND* Compilation of LD50 Values of New Drugs.  (J.R. MacDougal, Dept. of
   National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa,

Storage condition +4°C 4℃

其他信息

Sigma Aldrich:522-48-5(sigmaaldrich)
MOL 文件:522-48-5.mol