3-Methyladenine 6-氨基-3-甲基嘌呤
CAS 5142-23-4 MFCD00010531
信息真实价格透明
资金保障
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信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Bases & Related Reagents
- {SNA} Autophagy, Autophagy Inhibitors, Biochemicals and Reagents, Cell Signaling and Neuroscience, Core Bioreagents, Nucleoside Analogs, Nucleosides and Nucleotides, Nucleosides, Nucleotides, Oligonucleotides, Research Essentials, 细胞生物学
- Nucleotides
- Inhibitors
- Heterocycles
- {SNA} Autophagy, Autophagy Inhibitors,
产品应用
- 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K). For use as an autophagy inhibitor, 3-MA is typically used at a concen
相关文献及参考
- [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
- [3]. Wang X, et al. Acanthopanax versus 3-Methyladenine Ameliorates Sodium Taurocholate-Induced Severe Acute Pancreatitis by Inhibiting the Autophagic Pathway in Rats.Mediators Inflamm. 2016;2016:8369704.
- Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006),
- Hayat, M., et al.: Oncologist, 12, 20 (2007),
- Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001),
- [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
- [1]. Miller S, et al. Finding a fitting shoe for Cinderella: searching for an autophagy inhibitor. Autophagy. 2010 Aug;6(6):805-7.
- [2]. Hou H, et al. Inhibitors of phosphatidylinositol 3'-kinases promote mitotic cell death in HeLa cells. PLoS One. 2012;7(4):e35665.
- [3]. Wang X, et al. Acanthopanax
安全信息
GHS Symbol
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P302+P352+P332+P313+P362+P364
- P332+P313
- P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛,皮肤或衣服。
- P305+P351+P338+P337+P313
- H315 Causes skin irritation 会刺激皮肤
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 280 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 46(5),104,1983