Acipimox 阿西莫司
CAS 51037-30-0 MFCD00865757
化学结构图
SMILES: CC1C=NC(=C[N+]=1[O-])C(O)=O
化学属性
| Mol. Formula | C6H6N2O3 |
|---|---|
| Mol. Weight | 154.13 |
| Melting Point | 177-180 °C |
别名和识别编码
| Chemical Name | Acipimox |
|---|---|
| CAS Number | 51037-30-0 |
| Alfabeta Name | CARBOXYMETHYLPYRAZINEOXIDE 521---- |
| MDL Number | MFCD00865757 |
| Synonym | 2-Carboxy-5-methylpyrazine 4-oxide 2-Carboxy-5-methylpyrazine 4-oxide 5-Methylpyrazinecarboxylic acid 4-oxide 5-Methyl-2-pyrazinecarboxylic Acid 4-Oxide 5-Methyl-2-pyrazinecarboxylic acid 4-oxide 5-Methylpyrazinecarboxylic Acid 4-Oxide 5-Methylpyrazinecarboxylic acid 4-oxide Acipimox K 9321 Olbemox Olbetam |
| EC Number | 256-928-3 |
| Reaxys-RN | 777471 |
| Beilstein Registry Number | 25(5)4,200 |
| Merck Number | 111 |
| Chemical Name Translation | 阿西莫司 |
| PubChem Substance ID | 135726995 |
| Wiswesser Line Notation | T6N DNJ AO B1 EVQ |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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现货库存
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分类
- Nutrition Research, Vitamin B, Vitamin B3, Vitamins
- {SNA} Vitamin B, Vitamin B3, Vitamins, 生化试剂
- {SNA} Vitamin B, Vitamin B3, Vitamins, 细胞生物学, 营养研究
产品应用
- Antilipemic.
相关文献及参考
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- 1. Lovisolo, P. P. et al., Pharmacological profile of a new antilipolytic agent: 5-methyl-pyrazine-2-carboxylic acid 4-oxide (acipimox) II — Antilipolytic and blood lipid lowering activity. Pharmacol. Res. Commun. 13 , 163-174, (1981)
- Gormsen LC, Gjedsted J, Gjedde S, et al., Free fatty acids decrease circulating ghrelin concentrations in humans. Eur. J. Endocrinol. 154 , 667-673, (2006) 摘要
- Lucidi P, Rossetti P, Porcellati F, et al., Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis. Diabetes 59 , 1349-1357, (2010) 摘要
- Montecucco F, Bertolotto M, et al., Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome. Am. J. Physiol. Endocrinol. Metab. 300 , E681-E690, (2011) 摘要
- Merck 14 ,111
安全信息
GHS Symbol
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P305+P351+P338+P337+P313
- P337+P313
- P305+P351+P338
- H319 Causes serious eye irritation 严重刺激眼睛
- H303 May be harmfully swallowed 吞食可能有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3500 mg/kg TOXIC EFFECTS : Biochemical - Metabolism (Intermediary) - lipids including transport REFERENCE : EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 15,157,1980
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36 Irritating to eyes 刺激眼睛
