IsoproterenolHydrochloride 盐酸异丙肾上腺素

CAS 51-30-9 MFCD00012603

化学结构图

51-30-9
SMILES: CC(C)NCC(O)c1ccc(O)c(O)c1.Cl

化学属性

Mol. FormulaC11H18ClNO3
Mol. Weight248
Melting Point165-175
SolubilityDMSO 50 mg/mL Water 50 mg/mL Ethanol <1 mg/mL
TSCANo
Appearance 白色或类白色结晶粉未，无臭，味微苦，遇光和空气渐渐变色。

别名和识别编码

Chemical NameIsoproterenolHydrochloride
Synonym (±)-Isoproterenol hydrochloride 1-(3',4'-Dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride N-Isopropyl-DL-noradrenaline hydrochloride (+/-)-ISOPROTERENOL HYDROCHLORIDE (±)-Isoproterenol hydrochloride 1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, 1,[3',4'-DIHYDROXYPHENYL]-2-ISOPROPYLAMINOETHANOL HYDROCHLORIDE 3,4-DIHYDROXY-ALPHA-[(ISOPROPYLAMINO)METHYL]BENZYLALCOHOL HYDROCHLORIDE 3,4-Dihydroxy-alpha-((isopropylamino)methyl)-benzyl alcohol hydrochloride; 4-(1-Hydroxy-2-((methylethyl)amino)ethyl)-1,2-benzenediol hydrochlo DL-ISOPROTERENOL HYDROCHLORIDE ISOPRENALINE HCL ISOPROPYLARTERENOL HYDROCHLORIDE Isoprenaline hydrochloride Isoproterenol hydrochloride N-ISOPROPYL-DL-NORADRENALINE HYDROCHLORIDE euspiran isadrine 盐酸异丙肾上腺素
MDL NumberMFCD00012603
CAS Number51-30-9
Beilstein Registry Number3917363
EC Number200-089-8
PubChem Substance ID5807
Merck Number14,5217
Chemical Name Translation盐酸异丙肾上腺素
Reaxys-RN3917363
Wiswesser Line NotationQR BQ DYQ1MY1&1 &GH
LabNetwork Molecule IDLN00199674
InChIInChI=1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
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分类

  • {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Biochemicals and Reagents, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, I, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, Proteins and Derivatives, Sanofi Aventis, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • {SNA} Analytical Standards, Analytical/C
  • {SNA} Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,

相关文献及参考

  • [2]. Vannucci SJ, et al. Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J. 1992 Nov 15;288 (Pt 1):325-30.
  • [3]. Delpy E, et al. Effects of cyclic GMP elevation on isoprenaline-induced increase in cyclic AMP and relaxation in rat aortic smooth muscle: role of phosphodiesterase 3. Br J Pharmacol. 1996 Oct;119(3):471-8.
  • [4]. Muller FU, et al. Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart. Circ Res. 1993 Mar;72(3):696-700.
  • [5]. Lei M, et al. Modulation of delayed rectifier potassium current, iK, by isoprenaline in rabbit isolated pacemaker cells. Exp Physiol. 2000 Jan;85(1):27-35.
  • [1]. Degerman E, et al. Evidence that insulin and isoprenaline activate the cGMP-inhibited low-K m cAMP phosphodiesterase in rat fat cells by phosphorylation. Proc Natl Acad Sci U S A. 1990 Jan;87(2):533-7

安全信息

GHS Symbol
WGK Germany2
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H303 May be harmfully swallowed 吞食可能有害
RTECSDO1925000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S37 Wear suitable gloves 戴适当手套；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 储存温度-20°C 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   1,443,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 77 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   V

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 3070 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,119,

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TOVEFN Toksikologicheskii Vestnik.  (18-20 Vadkovskii per.  Moscow, 101479,
   Russia) History Unknown  Volume(issue)/page/year: (5),40,1995

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 26900 ug/kg
TOXIC EFFECTS :
   Sense Organs and Sp

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 3333 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 5 umol/L
REFERENCE :
   INOPAO Investigative Ophthalmology.  (St. Louis, MO)  V.1-15, 1962-76.  For
   publisher information, see IOVSDA.  Volume(issue)/page/year: 13,210,1974

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 400 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 13 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 10 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-211466

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 5 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-211466

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2500 ug/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB83-211466

其他信息

  • MSDS 信息:4-(1-Hydroxy-2-((methylethyl)amino)ethyl)-1,2-benzenediol hydrochloride(51-30-9).msds
  • 图谱信息:盐酸异丙肾上腺素(51-30-9)红外图谱(IR2) 盐酸异丙肾上腺素(51-30-9)核磁图( 1 HNMR) 盐酸异丙肾上腺素(51-30-9)核磁图( 13 CNMR) 盐酸异丙肾上腺素(51-30-9)质谱(MS) 盐酸异丙肾上腺素(51-30-9)红外图谱(IR1)
  • Sigma Aldrich:51-30-9(sigmaaldrich)
  • TCI Shanghai:异丙肾上腺素盐酸盐 Isoproterenol Hydrochloride,>;99.0%(T)(51-30-9)
  • 用途一:适用于治疗支气管哮喘发作，也适用于慢性肺气肿
  • Isoprenaline hydrochloride
  • F:3-8-10
  • 盐酸异丙肾上腺素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/04/16 I0260 异丙肾上腺素盐酸盐 Isoproterenol Hydrochloride 25G 857元
  • MOL 文件:51-30-9.mol
  • 盐酸异丙肾上腺素价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 I0260 异丙肾上腺素盐酸盐 Isoproterenol Hydrochloride 25G 1320元

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. I - Bioactive Small Molecules
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Oxygen Compounds 氧化合物
  5. Amino Alcohols - Oxygen Compounds
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Medical Research Areas
  2. GPCR & G Protein
  3. Adrenergic Receptor  (肾上腺素能受体)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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