5-(4-Fluorophenyl)-2-Urea Thiophene-3-Formamide 5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺
CAS 507475-17-4 MFCD09037541
化学结构图
SMILES: NC(=O)Nc1sc(-c2ccc(F)cc2)cc1C(N)=O
化学属性
| Mol. Formula | C12H10FN3O2S |
|---|---|
| Mol. Weight | 279 |
| Appearance | Solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 5-(4-Fluorophenyl)-2-Urea Thiophene-3-Formamide |
|---|---|
| Synonym | GW683965 GW683965 GW683965A [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide GW683965A TPCA-1 TPCA1; TPCA 1; TPCA1 [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide |
| MDL Number | MFCD09037541 |
| PubChem Substance ID | 329826675 |
| CAS Number | 507475-17-4 |
| Chemical Name Translation | 5-(4-氟苯基)-2-脲基噻吩-3-甲酰胺 |
| Formula | C12H10FN3O2S |
| IUPAC Name | 5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide |
| InChIKey | SAYGKHKXGCPTLX-UHFFFAOYSA-N |
| InChI | InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18) |
| Canonical SMILES | O=C(C1=C(NC(N)=O)SC(C2=CC=C(F)C=C2)=C1)N |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, I Kappa B Kinase (IKK), Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, I Kappa B Kinase (IKK), Kinase/Phosphatase Biology, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, T, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- TPCA-1 is a potent IKK-2 inhibitor. TPCA-1 is also an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation in vivo. It selectively repressed proliferation of NSCLC cells with constitutive STAT3 activation. TPCA-1 as a direct dual inhibitor for both IKKs and STAT3, whereas treatment targeting EGFR only could not sufficiently repress NF-κB and STAT3 pathways for lung cancers harboring mutant EGFR. Therefore, synergistic treatment of TPCA-1 with TKIs has potential to be a more effective strategy for cancers.
安全信息
GHS Symbol
- P301+P312+P330
- P305+P351+P338
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36 Irritating to eyes 刺激眼睛
- R22 Harmful if swallowed 吞咽有害
