Benzamidine, 4,4'-(pentamethylenedioxy)di-,dihydrochloride
CAS 50357-45-4 MFCD01667907
化学结构图
SMILES: Cl.Cl.NC(=N)C1C=CC(=CC=1)OCCCCCOC1C=CC(=CC=1)C(N)=N
化学属性
| Mol. Formula | C19H24N4O2.2ClH |
|---|---|
| Mol. Weight | 413.39 |
别名和识别编码
| Chemical Name | Benzamidine, 4,4'-(pentamethylenedioxy)di-,dihydrochloride |
|---|---|
| Wiswesser Line Notation | MUYZR DO5OR DYZUM &GH 2 |
| Synonym | 4,4'-Diamidino-1,5-diphenoxypentane dihydrochloride Pentamidine dihydrochloride |
| CAS Number | 50357-45-4 |
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相关文献及参考
- [2]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.
- [3]. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.
- [4]. David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections? J Lab Precis Med 2017;2:49.
- [1]. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.
- [1]. Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64.
- [2]. Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400.
- [3]. Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34.
- {MCE
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 28 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - body temperature decrease REFERENCE : ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton, Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year: 37,1,1943
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 64 mg/kg TOXIC EFFECTS : Brain and Coverings - recordings from specific areas of CNS Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - body temperature decrease REFERENCE : ATMPA2 Annals of Tropical Medicine and Parasitology. (Grune & Stratton, Inc., POB 6280, Duluth, MN 55806) V.1- 1907- Volume(issue)/page/year: 37,1,1943
