Trichloromethyl Chloroformate 氯甲酸三氯甲酯
CAS 503-38-8 MFCD00015553
化学结构图
SMILES: O=C(Cl)OC(Cl)(Cl)Cl
化学属性
| Mol. Formula | C2Cl4O2 |
|---|---|
| Mol. Weight | 198 |
| Refractive index | n20/D 1.458 |
| Boiling Point | 20 °C/10 mmHg(lit.) |
| Density | 1.639 g/mL at 20 °C |
| Flash Point | >110°(230°F) |
| TSCA | Yes |
| Melting Point | -57° |
| Solubility | MAY DECOMPOSE |
别名和识别编码
| Chemical Name | Trichloromethyl Chloroformate |
|---|---|
| Synonym | Carbonochloridicacid,trichloromethylester DIPHOSGENE Carbonochloridic acid, trichloromethyl ester DP Trichloromethyl chlorocarbonate Trichloromethyl chloroformate chloro-formicacitrichloromethylester Trichloromethylchloroformate=Diphosgene chlorocarbonic acid trichloromethyl ester 氯甲酸三氯甲酯 Chloroformic acid trichloromethyl ester Trichloromethylchloroformate,98% Disphosgene 雙光氣 CHLOROFORMIC ACID TRICHLOROMETHYL ESTER Formic acid, chloro-, trichloromethyl ester 氯代甲酸三氯甲酯 Difosgen Perchlorameisensäuremethylester trichlormethylesterkyselinychlormravenci trichloromethyl carbonochloridate 氯甲酸三氯甲基酯(双光气)/0401禁空运 phosgene dimer Perstoff Diphosgene Trichlormethyl-chlorformiat Chlorameisensäure-trichlormethylester 双光气 氯代甲酸三氯甲酯 Methanol, trichloro-, chloroformate TRICHLOROMETHYL CHLOROFORMATE 双光气 carbonochloridicacidtrichloromethylester trichloro-methanochloroformate Chlorameisensäuretrichlormethylester trochloromethylchloroformate perchloromethylformate Carbonochloridic acid trichloromethyl ester Trichlormethylester kyseliny chlormravenci Trichlormethylchlorformiat Diphosgen |
| CAS Number | 503-38-8 |
| PubChem Substance ID | 10426 |
| EC Number | 207-965-9 |
| Beilstein Registry Number | 970225 |
| MDL Number | MFCD00015553 |
| Merck Number | 14,3334 |
| Chemical Name Translation | 氯甲酸三氯甲酯 |
| Wiswesser Line Notation | GXGGOVG |
| LabNetwork Molecule ID | LN00851989 |
| InChI | InChI=1S/C2Cl4O2/c3-1(7)8-2(4,5)6 |
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分类
- {SA} Chemical Synthesis, Deprotecting Reagents, Others, Protection and Derivatization, Synthetic Reagents
- {uni_hamburg} no charge; carbonyl chloride; 1fragment
- {SNA} Chemical Synthesis, Deprotecting Reagents, Other Deprotecting Reagents, Protection and Derivatization, Synthetic Reagents
产品应用
- 光气替代物；原位炭催化分解成光气以及和氨基酸反应，生成N-羧基酸酐。
相关文献及参考
- Merck: 14,3334 Beilstein: 3,IV,33
- Convenient replacement for phosgene in many reactions, for example:
- Dehydration of N-monosubstituted formamides to isocyanides: Angew. Chem. Int. Ed., 16, 259 (1977).
- Short: III/38B
- See also Triphosgene, A14932, and Oxalyl chloride, A18012.
- Conversion of amines to isocyanates: J. Org. Chem., 41, 2070 (1976); Org. Synth. Coll ., 6, 715 (1988). For aliphatic amines, best results were obtained in the presence of the hindered amine 1,8-Bis(dimethylamino)naphthalene, L00313: J. Org. Chem., 61, 3883 (1996).
- Formation of nitriles from oximes Synthesis, 1037 (1986); or carboxamides: Tetrahedron Lett., 27, 2203 (1986).
- Merck: 14,3334
安全信息
GHS Symbol
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- H330 Fatal if inhaled 吸入致命
- H300 Fatal if swallowed 吞食致命
- H300+H330
- H302 Harmful if swallowed 吞食有害
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P303+P361+P353
- P304+P340+P310
- P305+P351+P338
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P301+P310
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- R26/27/28 Very toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有剧毒
- R34 Causes burns 会导致灼伤
- R26 Very toxic by inhalation 吸入极毒
- R26/28 Very toxic by inhalation and if swallowed 吸入及吞食都有剧毒
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S27/28
- S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 900 mg/m3/15M TOXIC EFFECTS : Lungs, Thorax, or Respiration - ciliary function changes Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes REFERENCE : FMORAO Folia Morphologica (Prague). (Plenum Pub. Corp. 233 Spring St., New York, NY 10013) V.13- 1965- Volume(issue)/page/year: 19,5,1971
其他信息
- 用途一:用作军用毒气及有机合成工业的原料
- F:8-10-19
- 储运特性:库房通风低温干燥; 与氧化剂、碱类、活性碳、食品添加剂分开存放
- 外观性质:无色液体，有窒息性。
- 毒性分级:中毒
- 急性毒性:吸入- 小鼠 LC50: 3600 毫克/ 立方米/ 10分; 吸入-兔子 LCL0: 900 毫克/立方米/15分
- Sigma Aldrich:503-38-8(sigmaaldrich)
- Alfa Aesar:氯甲酸三氯甲酯,98% Trichloromethyl chloroformate, 98%(503-38-8)
- 可燃性危险特性:遇热、或遇碱、或接触活性碳分解有毒光气; 遇水、水蒸气产生有毒气体; 受热产生有毒氯化物烟雾
- MOL 文件:503-38-8.mol
- 氯甲酸三氯甲酯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/06/21 243310100 氯甲酸三氯甲酯 Diphosgene 99% 10 ML 1170元 2010/06/21 243311000 氯甲酸三氯甲酯 Diphosgene 99% 100 ML 8521元 2010/05/25 A17444 氯甲酸三氯甲酯, 98% Trichloromethyl chloroformate, 98% 250g 5894元
- MSDS 信息:氯代甲酸三氯甲酯(503-38-8).msds
- 用途二:用于医药、农药、染料。
- 下游产品:氯甲酸苄酯 --> 苯磺隆 --> 4-叔丁氧羰基-2-甲基哌嗪 --> 杀扑磷 --> 3-二已胺荃-1-丙胺
- 类别:有毒物品
- 敏感性:Moisture Sensitive
- 用途三:光气替代物；原位炭催化分解成光气以及和氨基酸反应，生成N-羧基酸酐。
- 遇热或活性炭则分解，放出光气，亦能被热水或碱类分解。有刺激性，毒性较强，具有窒息性。溶于乙醇、乙醚和苯。
- Acros Organics:氯甲酸三氯甲基酯 Diphosgene, 99%(503-38-8)
