CAS 486-84-0 MFCD00004957-1-Methyl-9H-pyrido[3,4-b]indole 1-甲基-9H-吡啶并[3,4-b]吲哚 TAO{mole}

1-Methyl-9H-pyrido[3,4-b]indole 1-甲基-9H-吡啶并[3,4-b]吲哚

CAS 486-84-0 MFCD00004957

化学结构图

SMILES: Cc1nccc2c1[nH]c1ccccc12

化学属性

Mol. Formula	C12H10N2
Mol. Weight	182.22
Melting Point	235-238 °C
Boiling Point	305.62 °C at 760 mmHg

别名和识别编码

Chemical Name	1-Methyl-9H-pyrido[3,4-b]indole
CAS Number	486-84-0
Alfabeta Name	METHYLCARBOLINE BETAH19----
MDL Number	MFCD00004957
Synonym	Harmane {LY} Harmane {} {LY} Harmane {} {} {LY} Harmane {} {} {} {LY} Harmane {} {} {} {} {LY} Harmane {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Harmane {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
PubChem Substance ID	5281404
Beilstein Registry Number	0143898
EC Number	207-642-2
Chemical Name Translation	1-甲基-9H-吡啶并[3,4-b]吲哚
Merck Number	13,4630
Wiswesser Line Notation	T B656 EN HMJ F
LabNetwork Molecule ID	LN00143991
InChI	InChI=1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
Canonical SMILES	CC1=NC=CC2=C1NC3=C2C=CC=C3

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分类

{SNA} Analytical Reagents, Analytical/Chromatography, Mass Spectrometry (MS), Matrix Substances for MALDI-MS, Spectroscopy
{SNA} Bioactive Small Molecules, Building Blocks, Carbazoles, Cell Biology, Cell Signaling and Neuroscience, Chemical Synthesis, Cichorium intybus (Chicory), Glycan Labeling and Analysis, Glycobiology, H, Heterocyclic Building Blocks, Matricies for Mass Spectroscopy Analysis of Glycans, Neurobiology, Neuroscience, Nutrition Research, Pharmacologicals, Phytochemicals by Plant (Food/Spice/Herb), Post-Translational Modification,
{SNA} Mass Spectrometry (MS), Matrix Substances for MALDI-MS,
{SNA} Mass Spectrometry (MS),

产品应用

Harman alkaloid like harmane, harmine, harmalol, harmaline obtained from Banisteriopsis caapi L. showed cytotoxicity, antimicrobial activity against Staphylococcus aureus, Escherichia coli, Proteus vu

安全信息

Warnings IRRITANT

RTECSUV0280000

WGK Germany3

Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter

Packing GroupIII

Hazard Codes Xn

Hazard Class6.1(b)

UN Number 1544

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；

Risk Statements

R20/21 Harmful by inhalation and in contact with skin 吸入及与皮肤接触有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,164,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1400 mg/kg/4W (Continuous)
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   42,179,1988

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 100 mg/L
REFERENCE :
   CALEDQ Cancer Letters (Shannon, Ireland).  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1975- Volume(issue)/page/year:
   17,249,1983

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 208,39,1988

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 90,433,1981

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Cells - not otherwise specified
DOSE/DURATION           : 200 umol/L
REFERENCE :
   BBRCA9 Biochemical and Biophysical Research Communications.  (Academic
   Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1959-
   Volume(issue)/page/year: 86,124,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 150 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam,

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

其他信息

可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
Sigma Aldrich:486-84-0(sigmaaldrich)
MOL 文件:486-84-0.mol
毒性分级:高毒
哈尔满碱价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 146965000 哈尔满碱 Harmane 98% 500 MG 660元
图谱信息:哈尔满碱(486-84-0)红外图谱(IR2) 哈尔满碱(486-84-0)红外图谱(IR1) 哈尔满碱(486-84-0)质谱(MS)
急性毒性:腹腔-小鼠 LD50: 50 毫克/公斤; 皮下-兔子 LD50: 200 毫克/公斤
Acros Organics:Harmane, 98%(486-84-0)
储运特性:库房通风低温干燥; 与食品原料分开存放
灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
类别:有毒物品