Ellagic acid 柔花酸

CAS 476-66-4 MFCD00006914

化学结构图

476-66-4
SMILES: O=c1oc2c(O)c(O)cc3c(=O)oc4c(O)c(O)cc1c4c23

化学属性

Mol. FormulaC14H6O8
Mol. Weight302
Melting Point300
Density1.667
Solubility<0.1 G/100 ML AT 21 ºC
Appearance powder
Stability对空气敏感，对光敏感
Boiling Point

别名和识别编码

Chemical NameEllagic acid
Synonym 2,3,7,8-Tetrahydroxy(1)benzopyrano(5,4,3-cde)(1)benzopyran-5,10-dione 4,3-cde][1]benzopyran-5,10-dione,2,3,7,8-tetrahydroxy-[1]-Benzopyrano[5 4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID 2,6,2',6'-DILACTONE 4,4',5,5',6,6'-HEXAHYDROXYDIPHENIC ACID DILACTONE 4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone 4,4′,5,5′,6,6′-Hexahydroxydiphenic acid 2,6,2′,6′-dilactone AKOS NCG1-0028 Acid, Benzoaric Acid, Ellagic Benzoaric Acid Benzoaric acid Elagostasine Ellagic Acid Lagistase alizarineyellow c.i.75270 lagistase 二缩双(三羟基苯甲酸) 倍原 土耳其鞣酸 棓原;逆没食子酸,二缩双(三羟基甲酸); 2,3,7,8-四羟基-[1]-苯并吡喃并[5,4,3-CDE][1]苯并吡喃-5,10-二酮 逆没食子酸 鞣花酸二水化合物 鞣花酸水合物
MDL NumberMFCD00006914
Beilstein Registry Number47549
CAS Number476-66-4
EC Number207-508-3
PubChem Substance ID5281855
Chemical Name Translation柔花酸
Merck Number3547
Reaxys-RN47549
LabNetwork Molecule IDLN00196863
InChIInChI=1S/C14H6O8/c15-5-1-3-7-8-4(14(20)22-11(7)9(5)17)2-6(16)10(18)12(8)21-13(3)19/h1-2,15-18H
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分类

  • {SNA} Additional Standards, Alphabetical, Analytical Standards, Arctostaphylos, Chromatography, E - H, Eucalyptus, Life Sciences Standards, Natural Compounds, Phyllanthus, Phytochemicals Standards, Potentilla, Punica, Standards by Plant Genus, Substance Classification, Syzygium, Tannins, Terminalia, Tilia, 分析/色谱
  • {SNA} Additional Standards, Alphabetical Index of Phytochemical Standards, Analytical Standards, Arctostaphylos, Chromatography, E - H,
  • {SNA} Antioxidant and Free Radical

产品应用

  • 常见于多酚植物。谷胱甘肽S-转移酶的抑制剂，常用于检测血浆中XIIa 因子；抗氧化剂；DNA双链的保护剂。

相关文献及参考

  • [2]. Rizk HA, et al. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12).
  • [3]. Ahire V, et al. Ellagic Acid Enhances Apoptotic Sensitivity of Breast Cancer Cells to γ-Radiation. Nutr Cancer. 2017 Aug-Sep;69(6):904-910.
  • Merck: 14,3547
  • Merck: 14,3547 Beilstein:19,261
  • [1]. Cozza G, et al. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6.
  • [1]. Cozza G, et al. Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application. J Med Chem. 2006 Apr 20;49(8):2363-6.
  • [2]. Rizk HA, et al. Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol. 2017 Dec;31(12).
  • [3]. Ahire V, et al. Ellagic Acid E

安全信息

GHS Symbol
RTECSDJ2620000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P350
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany1
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes Xi
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 充氩密封避光保存。 对光和空气敏感，充氩密封避光保存。 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 1208 mg/kg
SEX/DURATION            : female 16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
   Reproductive - Specific Developmental Abnormalities - blood and lymphatic
   systems (including spleen and marrow)
REFERENCE :
   AMBPBZ Acta Pathologica et Microbiologica Scandinavica, Section A:
   Pathology.  (Copenhagen, Denmark) V.78-89, 1970-81.  For publisher
   information, see ACPADQ.  Volume(issue)/page/year: 79,487,1971

UN Number
Packing Group

其他信息

  • Alfa Aesar:鞣花酸二水合物,97% Ellagic acid hydrate, 97%, may cont. up to 12% water(476-66-4)
  • color:tan to gray
  • 对光和空气敏感。溶于碱类和吡啶，微溶于水和乙醇，几乎不溶于乙醚。。有刺激性。商品也有含2分子结晶水的。
  • 鞣花酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 E0375 鞣花酸二水合物 Ellagic Acid Dihydrate 5G 530元 2014/06/02 E0375 鞣花酸二水合物 Ellagic Acid Dihydrate 25G 1580元 2010/05/25 A15722 鞣花酸二水合物, 97% Ellagic acid hydrate, 97%, may cont. up to 12% water 25g 1512元
  • Acros Organics:鞣花酸水合物 Ellagic acid hydrate, 97%(476-66-4)
  • MSDS 信息:4,4',5,5',6,6'-Hexahydroxydiphenic acid 2,6,2',6'-dilactone(476-66-4).msds
  • MOL 文件:476-66-4.mol
  • 用途一:用于医药及化妆品，作抗氧剂，具有防癌及抑制病毒作用
  • 敏感性:Air & Light Sensitive
  • 图谱信息:鞣花酸(476-66-4)质谱(MS) 鞣花酸(476-66-4)红外图谱(IR2) 鞣花酸(476-66-4)红外图谱(IR1)
  • TCI Shanghai:鞣花酸 Ellagic Acid Dihydrate(476-66-4)
  • F:8-10-23
  • Sigma Aldrich:476-66-4(sigmaaldrich)

系列性分类

  1. Life Science 生命科学
  2. Cancer Research
  3. Chemopreventive Agents - Cancer Research
  4. Antioxidant and Free Radical Scavengers - Chemopreventive Agents
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Ephedra sinica - Phytochemicals by Plant (Food/Spice/Herb)
  1. Life Science 生命科学
  2. Nutrition Research 营养研究
  3. Phytochemicals by Plant (Food/Spice/Herb) - Nutrition Research
  4. Euphorbia sp - Phytochemicals by Plant (Food/Spice/Herb)
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Phytopharma Standards - Life Sciences Standards
  6. Alphabetical - Phytopharma Standards
  7. E - H - Alphabetical
  1. Functional Group 官能团索引
  2. 1,2-diphenol
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Enzymes, Inhibitors, and Substrates
  4. Protein Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Biochemicals Found in Plants
  4. Lipids
  5. Polyunsaturated
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Nitric Oxide and Cell Stress
  5. Cell Stress
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Proteins and Derivatives
  4. Proteins for Cell Biology
  5. Kinases and Phosphatases
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Cell Signaling and Neuroscience
  4. Peptides and Proteins
  5. Proteins for Cell Biology
  6. Immune System Proteins
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Nutrition Research
  4. Biochemicals Found in Plants
  5. Lipids
  6. Polyunsaturated
  1. Medical Research Areas
  2. Metabolism
  3. Reactive Oxygen Species  (活性氧)
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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