Alvespimycin 阿螺旋霉素
CAS 467214-20-6 MFCD09026908
化学结构图
SMILES: Cl.CC1=C[C@H](C)[C@@H](O)[C@H](C[C@H](C)CC2=C(NCCN(C)C)C(=O)C=C(NC(=O)C(C)=CC=C[C@H](OC)[C@H]1OC(N)=O)C2=O)OC |c:1,30,t:28|
化学属性
| Mol. Formula | C32H48N4O8.ClH |
|---|---|
| Mol. Weight | 653.212 |
别名和识别编码
| Chemical Name | Alvespimycin |
|---|---|
| Chemical Name Translation | 阿螺旋霉素 |
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相关文献及参考
- [2]. Hertlein E, et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition. Blood. 2010 Jul 8;116(1):45-53.
- [3]. Henke A, et al. Reduced Contractility and Motility of Prostatic Cancer-Associated Fibroblasts after Inhibition of Heat Shock Protein 90. Cancers (Basel). 2016 Aug 24;8(9). pii: E77.
- [1]. Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.
- [1]. Ge J, et al. Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90. J Med Chem. 2006 Jul 27;49(15):4606-15.
- [2]. Hertlein E, et al. 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic l
